小儿激素依赖性肾病综合征长期激素治疗对生长发育的影响  

Growth retardation in children with Steroid-dependent nephrotic syndrome on long glucocorticoids therapy

作　　者：孙琳琳[1] 梅长林[1] 赵学智[1] 贾洁爽[1] 刘洁琼[1] 张宏[1] 

机构地区：[1]第二军医大学长征医院肾内科解放军肾病研,上海200003

出　　处：《临床肾脏病杂志》2007年第4期174-175,共2页Journal Of Clinical Nephrology

摘　　要：目的探讨难治性肾病综合征及糖皮质激素治疗对小儿生长发育的影响，增强对小儿肾病综合征生长发育迟缓的防治意识。方法针对1例病情长期未得到良好控制的激素依赖性肾病综合征并发垂体性侏儒症的患儿成功诊治经验，回顾分析激素依赖性肾病综合征对患儿生长发育影响的相关文献。结果肾病综合征疾病本身及糖皮质激素长期应用都会对患儿生长发育造成影响，具体机制还不清楚。结论在治疗小儿肾病综合征时，应尽可能对初发病例采用较短疗程的治疗方案。对此患儿应避免长期使用激素，可换用其它免疫抑制剂，并注意监测身高和生长速度，必要时可加用毕长激索治疗．Objective To discuss the growth retardation in childrine with refractory nephrotic syndrome on long ferm glueocorticoids therapy. Method Literatures were reviewed to evaluate the impact of steroid-dependent syndrome and chronic glucocorticoids on growth of children. A case report of one nephrotic child who was glucocorticoid dependent present growth retardation and short stature. Results The mechanism was uncertain, but both chronic glucocorticoids and nephrotic syndrome night independently affect growth. There was no similar literature nelated to the short stature child as we reported yet. Conclusions Newly diagnosed nephrotic children should be treated with glucocortiods with short period of time. Steroid-resistance or steroid-dependent children should be supervised on their stature and growth velocity, If nephrotic syndrome is not necovered long ferm glucocorticoids shoned be avoided. Other immunosuppressant may be usedos altemative and growth hormone may be supplemented nessesary.

关 键 词：肾病综合征 糖皮质激素 生长 

分 类 号：R726.92[医药卫生—儿科]