彩色多普勒能量显像对糖尿病视网膜病变眼血流动力学的研究  

The evaluation of ocular hemodynamics in patients with diabetic retinopathy by color Doppler energy

作　　者：徐蔚[1] 王惠英[1] 江志坚[1] 仇许玲[1] 

机构地区：[1]同济大学附属同济医院眼科,上海200065

出　　处：《同济大学学报（医学版）》2007年第4期71-74,共4页Journal of Tongji University(Medical Science)

摘　　要：目的应用彩色多普勒能量显像(color doppler energy,CDE)技术检测糖尿病视网膜病变患者的眼球血流动力学变化。方法利用CDE技术,测定100例(200只眼)糖尿病视网膜病变患者及15例(30只眼)正常人眼动脉(ophthalmic artery,OA)及视网膜中央动脉(central retinal artery,CRA)的收缩期峰值流速(peak systolic velocity,PSV)、舒张末期峰值流速(end diastolic velocity,EDV)及阻力指数(resistive index,RI)。经眼底检查和眼底荧光造影检查,包括无明显视网膜病变(non-obvious diabetic retinopathy,NDR)25例,非增殖期糖尿病视网膜病变(non-pro-liferative diabetic retinopathy,NPDR))39例,增殖期糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)36例。结果与对照组比较,病例组OA的EDV明显减小,RI明显增大,差异有显著性(P<0.05),而PSV差异没有显著性(P>0.05)。病例组CRA的PSV、EDV明显减小,RI明显增大,差别有显著性(P<0.05)。EDV和RI的灵敏度优于PSV。结论随着糖尿病视网膜病变发展,糖尿病患者的眼球血流动力学发生进行性改变,应用CDE动态检测眼球血管血流动力学的变化对DRP的发病机制研究及早期诊治、预后具有重要临床意义。Objective To evaluate the ocular bemodynamies in patients with diabetic retinopathy （DRP）by color Doppler energy（CDE）. Methods Blood flow parameters of ophthalmic artery （OA） and central retinal artery （CRA） were assessed for 100 cases of patients with diabetic retinopathy and 15 cases of normal persons by CDE, and to get their peak systolic velocity （PSV）, end diastolic velocity （EDV） and resistive index （RI）. Results Compared with the control group, EDV of patients with DRP was slower and RI was higher obviously in OA. Both of EDV and PSV of patients with DRP were slower and RI was higher in CRA. There were significant differences between numerical values in all experimental groups （P 〈 0.05）, but PSV in OA （P 〉 0.05）. EDV and RI were more sensitive than PSV. Conclusion Following the progress of DRP, the ocular hemodynamics in patients with diabetes is carrying on. The evaluation of ocular hemodynamics by CDE has important clinical significance for early diagnosis,prognosis of DRP and its pathogenesis.

关 键 词：彩色多普勒能量显像 糖尿病视网膜病变 血流动力学 

分 类 号：R445.1[医药卫生—影像医学与核医学] R774.1[医药卫生—诊断学]