生物法转化分离耦合制备γ-癸内酯  

Simultaneous conversion and separation of γ-decalactone prepared by biological pathway

作　　者：于伟[1] 徐岩 喻晓蔚[1] 穆晓清[1] 

机构地区：[1]江南大学生物工程学院教育部工业生物技术重点实验室,江苏无锡214122

出　　处：《化工进展》2007年第8期1151-1154,共4页Chemical Industry and Engineering Progress

基　　金：长江学者和创新团队发展计划资助(IRT0532);新世纪人才支持计划项目(NCET-04-0498)

摘　　要：研究通过添加树脂AB-8吸附转化产物以降低高浓度产物对Yarrowia lypolitica细胞的毒性,进而提高产量。确定了蓖麻油添加量25 g/L、树脂量7.5%、pH值7.5的最佳优化工艺,产物的最大比生成速率提高36%且达到最大值后降低较慢,有利于产物积累,56 h后总产量达到2.17 g/L,耦合工艺在提高产量的同时又能较好地实现产物的分离。The product in the production of γ-decalactone by biological pathway has obvious toxicity to the growth of Yarrowia lypolitica.Resin AB-8 was added to adsorb converted product to reduce the toxicity on Yarrowia lypolitica.The optimum conditions were castor oil 25g/L, 7.5% AB-8, pH 7.5. The maximal specific γ -decalactone formation rate increased by 36% and decreased slowly after it reached a maximum, leading to better product accumulation. The total product concentration reached 2.17g/L after 56h. As a result, addition of resin not only increased the production but also separated the product.

关 键 词：Γ-癸内酯 树脂吸附 转化分离耦合 

分 类 号：TQ225.24[化学工程—有机化工]