帕金森病模型大鼠腹内侧前额叶皮层神经元的活动变化  

Changes of neuronal activity of ventromedial prefrontal cortex in the rat model of Parkinson's disease

作　　者：曹健[1] 刘健[1] 李强[1] 冯洁[1] 王涛[1] 王爽[1] 韩玲娜[1] 

机构地区：[1]西安交通大学医学院生理学与病理生理学系

出　　处：《第四军医大学学报》2007年第17期1555-1558,共4页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金(30370464)

摘　　要：目的:观察和分析帕金森状态下腹内侧前额叶皮层中神经元的活动变化.方法:以6-羟多巴胺(6-OHDA)毁损黑质致密部(SNc)建立的PD模型大鼠为研究对象,采用玻璃微电极细胞外记录方法,记录和分析了PD状态下腹内侧前额叶皮层中神经元的电活动变化.结果:对照组与PD组大鼠腹内侧前额叶皮层神经元的放电频率分别为(2.3±0.9)Hz和(4.2±2.0)Hz.与对照组相比,PD模型大鼠腹内侧前额叶皮层神经元的放电频率显著增高(P<0.001).结论:6-OHDA单侧毁损SNc的DA能神经元后,腹内侧前额叶皮层神经元的放电频率显著增高,表明正常大鼠中黑质对腹内侧前额叶皮层起抑制性作用.AIM： To observe and analyze the neuronal activity of ventromedial prefrontal cortex in normal and 6-OHDA-lesioned rats. METHODS： SD rat model of Parkinson＇s disease was established by lesion induction in substantia nigra compacta （SNc） by 6-hydroxydopamine. The neuronal activity of ventromedial prefrontal cortex in normal and 6-OHDA-lesioned rats was observed by capillary glass microelectrode extracelluar recording method. RESULTS： The mean firing rates of ventromedial prefrontal cortex neurons in normal and PD rats were （2.3± 0.9） Hz and （4.2 ±2.0） Hz, respectively. The mean firing rate of the neurons in PD rats was significantly increased compared to that in normal rats （P 〈0. 001 ）. CONCLUSION： The firing rate of ventromedial prefrontal cortex neurons is increased significantly in the rat model of PD, suggesting that substantia nigra（SN） inhibits the neuronal activity of the ventromedial prefrontal cortex neurons in the intact rat.

关 键 词：帕金森病 6-羟多巴胺 额叶前皮质 电生理 

分 类 号：Q426[生物学—神经生物学] R338.25[生物学—生理学]