老年冠心病颈动脉内膜中层厚度与血清脂联素水平的相关性研究  

Relationship between the IMT of common carotid artery and the serum level of adiponectin in elderly patients with coronary heart disease

作　　者：侯春兰[1] 周润锁[2] 张岁龙[1] 陈旭[1] 

机构地区：[1]西安交通大学医学院第二附属医院老年病科,陕西西安710004 [2]第四军医大学唐都医院核医学科,陕西西安710038

出　　处：《第四军医大学学报》2007年第17期1590-1592,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨老年冠心病患者颈动脉内膜中层厚度(IMT)与血清脂联素(APN)水平的相关性.方法:将68例老年冠心病患者根据颈动脉平均IMT分成3组:内膜增厚组、斑块形成组和管腔狭窄组.采用酶联免疫法测定血清APN水平,并与24例年龄和性别相当的健康体检者进行比较.结果:冠心病组血清APN为(9.8±4.2)mg/L,明显低于正常对照组的(13.9±4.7)mg/L,差异有显著性(P<0.01),且随颈动脉狭窄程度的增加,APN逐渐降低.中、重度狭窄组APN水平明显低于轻度组(P<0.05).结论:APN参与了老年冠心病患者颈动脉狭窄的发生和发展过程,与颈动脉狭窄病理生理改变关系密切.APN为评价颈动脉IMT病变程度提供了一条新的线索.AIM： To investigate the relationship between the intima-media thickness （IMT） of common carotid artery and the serum level of adiponectin （APN） in elder patients with coronary heart disease （CHD）. METHODS： Sixty-eight elder patients with CHD were divided into three groups according to the degree of the IMT： the intima thickening group, the plaque formation group and the vascular stenosis group. Serum APN was measured by ELISA, and compared with that in 24 healthy subjects. RESULTS： The serum level of APN in CHD patients [ （9.8±4.2） mg/L] was significantly lower than that in control group [ （13.9 ±4.7） mg/L]. The difference was significant between the two groups （P 〈 0.01 ）. In addition, the serum level of APN decreased with the increase of vascular stenosis extent. The serum APN levels in plaque formation group and vascular stenosis group were significantly lower than that in intima thickness group （ P 〈 0.05 ）. CONCLUSION： APN is significantly correlated with IMT, suggesting that APN is involved in the development of the vascular stenosis in the patients with CHD. APN may be a new marker for surveillance on IMT.

关 键 词：冠状动脉疾病 脂联素 老年人 

分 类 号：R541[医药卫生—心血管疾病]