N-杂环卡宾Pd络合物的合成及其在Buchwald-Hartwig反应中的应用  

Synthesis of N-Heterocyclic Carbene Palladacycle Complexes and Their Applications to Buchwald-Hartwig Reactions

作　　者：施继成[1] 曹新华[1] 郑瑛[1] 贾莉[1] 

机构地区：[1]福建师范大学化学与材料学院,福州350007

出　　处：《化学学报》2007年第16期1702-1706,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20473089)资助项目.

摘　　要：合成鉴定了两个N-杂环卡宾环金属Pd络合物[1,3-N,N'-双{2,6-二取代基苯基}咪唑啉基-2-亚基][2-N,N-二甲基胺基苯基-C,N]氯化钯(II)(3a:取代基=异丙基;3b:取代基=甲基),评价了它们在氯代芳烃和各种胺偶联反应中的催化性能.发现NaOBu-t是效果较好的碱,及Pd周围有较大的空间要求的3a在4-甲基氯苯与吗啡啉反应中较3b有更好的催化性能.　Two new N-heterocyclic carbene palladacycle complexes [1,3-N,N＇-bis（2,6-disubstituted phenyl）imidazolin-2-ylidene]chloro[2-dimethylaminomethylphenyl-C,N]palladium（II）[R=i-Pr（3a）,methyl（3b）] have been synthesized,and evaluated as catalyst precursors for aminations of aryl chlorides with various amine coupling partners.It was found that 3a with bulky substituents around Pd center is better than 3b for catalyzing the amination of 4-methylphenyl chloride with morpholine in the presence of sodium tert-butoxide.

关 键 词：N-杂环卡宾 PD催化剂 C—N键形成反应 

分 类 号：O621.2[理学—有机化学]