蚯蚓溶栓酶对大鼠凝血及纤溶指标的影响  

The Effect of Earthworm Fibrinolytic Emzyme on Blood Coagulation and Fibrinolytic Index in Rat

作　　者：段平[1,2] 胡淑丽[1,2] 曾耀辉 

机构地区：[1]湖北中医学院中心实验室 [2]清华大学生物科学与技术系

出　　处：《时珍国药研究》1997年第1期14-16,共3页

摘　　要：低剂量的溶栓酶用于大鼠能引起纤维蛋白原（Ｆｂｇ）平均下降４５％，凝血酶时间（ＴＴ）由１１．１３秒延长到２２．６３秒（Ｐ＜０．０１），而凝血酶原时间（ＰＴ）及白陶土部分凝血活酶时间（ＫＰＴＴ）无显著性变化（Ｐ＞０．０５）。但高剂量的溶栓酶除能明显降低Ｆｂｇ和延长ＴＴ外，而且可使ＰＴ由１６．８２秒延长到７３．４４秒及ＫＰＴＴ由４６．６３秒延长到１２４．１３秒，并能使Ⅱ、Ⅷ因子降解。The earthworm fibrinolytic enzyme injected in rats at a lower dosage (750μ/ml) resulted in decreased fibrinogen (Fbg) by av. 44% and prolonged thrombin time (TT) from 11.15 sec. to 22.63 sec. (P<0.01), while no obvious change were observed on the prothrombin time (PT) and kaolin partial thromboplastin time (KPTT) (Table 1). At a higher dosage (1500μ/ml), however, marked decrease of Fbg and marked prolongation of TT were observed. In addition, not only PT and KPTT both markedly prolonged, but also resulted in the degradation of factors I and VIII and hence strengthed the antithrombotic effect.

关 键 词：蚯蚓溶栓酶 凝血 纤溶 药理 

分 类 号：R282.740.5[医药卫生—中药学]