环丙基甲基酮的合成新方法  

A Novel Synthetic Method for 1-Cyclopropylethanone

作　　者：武祥龙[1] 韩洁[1] 贺怀贞[1] 史真[1] 

机构地区：[1]西北大学化学系,西安710069

出　　处：《应用化学》2007年第9期1077-1079,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20472067);高等学校博士学科点专项科研基金(20050697003);陕西省自然科学基金资助项目

摘　　要：以邻苯二胺和环丙基甲酸为原料,以多聚磷酸(PPA)为催化剂,在微波辐射下合成了环丙基苯并咪唑,用碘甲烷季胺化得到未见文献报道的环丙基苯并咪唑盐,通过苯并咪唑盐与Grignard试剂加成后水解反应制备环丙基甲基酮。经元素分析和红外光谱、质谱、核磁共振测试技术表征确证了结构。环丙基甲基酮为无色液体,合成环丙基甲基酮方法的产率为67%,为环丙基甲基酮提供了一种未见文献报道的合成方法。2-Cyclopropylbenzimidazole was synthesized from o-phenylenediamine and cyclopropanecarboxylic acid with polyphosphoric acid as the catalyst under microwave. An unreported compound 2-cyclopropylbenzimidazolium salt was obtained from 2-cyclopropyl benzimidazole and iodomethane. 1-Cyclopropylethanone was prepared via the addition-hydrolysis reaction of the 2-cyclopropyl benzimidazolium salt with a Grignard reagent. It was characterized by means of elemental analysis, IR, MS and ^1H NMR. The title compound is colorless oil. The yield was 67%. This synthetic method for preparation of 1-cyclopropylethanone has not been reported.

关 键 词：苯并咪唑盐 GRIGNARD试剂 环丙基甲基酮 合成 

分 类 号：O625[理学—有机化学]