蜂贝化瘀胶囊对糖尿病微血管病变相关指标的影响  

Effect of Fengbei Huayu Capsule on Diabetic Microangiopathy-Related Indexes

作　　者：段文卓[1] 宫海民[2] 金光香[1] 李曰庆[3] 

机构地区：[1]潍坊医学院病理生理教研室 [2]山东省潍坊市中医院 [3]北京中医药大学东直门医院

出　　处：《中医杂志》2007年第8期738-741,共4页Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2001-2-76)

摘　　要：目的观察蜂贝化瘀胶囊对2型糖尿病(DM)大鼠微血管病变的作用及机理。方法将Wistar大鼠分为正常对照组、DM模型组、中药治疗组、中药对照组和西药对照组,测定各组大鼠血糖、血脂、脂质过氧化物、糖基化终末产物、醛糖还原酶(AR)及相关基因表达的变化。结果DM模型组大鼠血糖、甘油三酯、糖化血红蛋白、AR活性、丙二醛和T细胞凋亡率均明显上升,T细胞中Fas配体(FasL)、脂肪细胞中肿瘤坏死因子α(TNF-α)基因表达均明显增高,中药治疗组大鼠以上指标显著降低,与DM模型组比较差异有显著性意义(P<0.05)。结论蜂贝化瘀胶囊能有效降低2型DM模型组大鼠的血糖、血脂、糖化血红蛋白、AR活性和丙二醛含量,减少相关基因表达和T细胞凋亡率,对2型DM微血管病变有较好的治疗作用。Objective To study effects and mechanism of Fengbei Huayu Capsule on microangiopathy caused by diabetes （DM） in Rats. Methods Wistar rats were devided into five groups including the control group, DM model group, Chinese medicine treatment group, positive Chinese medicine treatment control group and positive western medicine treatment control group. Serum glucose ,blood fat, lipid peroxidation, dead end product of glycosylation, aldose reductase （AR） and related gene expressions were determined. Results The DM model group of rats showed increase of serum glucose, triglyceride,glycosylated hemoglobin,activity of AR and malonaldehyde（MDA） as well as the increase of gene expression of FasL and TNF-α and apoptosis rates of T cells. However, the tested targets in Chinese medicine treatment group signficantly decreased （P〈0.05）after the treatment with Chinese medicine. Conclusion Fengbei Huayu Capsule could effectively decrease related gene expression and diabetes-caused increase of serum glucose, blood fat, lipid peroxidation, glycosylated hemoglobin,activity of AR and MDA, as well as apoptosis rats of T cells in DM rats. It has good therapeutic effects on microangiopathy caused by diabetes.

关 键 词：蜂贝化瘀胶囊 2型糖尿病 微血管病变 

分 类 号：R259[医药卫生—中西医结合]