镧系离子增敏发光技术在药物检测中的应用  

Application of Lanthanide(Ⅲ) Ions-sensitized Luminescence Technique for Drug Determination

作　　者：蒲夏[1] 何华[1,2] JIANGYan-zhou 

机构地区：[1]中国药科大学分析化学教研室,江苏南京210009 [2]药物质量与安全预警教育部重点实验室,江苏南京210009 [3]Laboratoire de Chimie Analytique, Faculte de Pharmacie,92296 Chatenay-Malabry Cedex,France

出　　处：《药学进展》2007年第8期353-358,共6页Progress in Pharmaceutical Sciences

基　　金：江苏省自然科学资助项目(BK2003080)

摘　　要：概述镧系离子(Ln3+)的发光特性及与有机配体之间的能量转移过程和影响因素,介绍Ln3+增敏发光技术直接及与干试剂化学技术、HPLC和毛细管电泳联合应用于药物检测。Ln3+增敏发光技术尤其适用于检测体内微量药物及其代谢产物,可排除生物样品中杂质的干扰,选择性和灵敏度高,应用前景广阔。The luminescence properties of lanthanide（Ⅲ） ions（Ln^3＋ ）, the energy transfer between Ln3＋ and organic ligands and the influence factors there of were summarized. The direct and dry reagent chemical teehno logy-, HPLC-, and CE-combined application of Ln^3＋ -sensitized luminescence technique for drug determination were introduced. The technique is especially suitable for in vivo micro-determination of drug and its metabolites, which can obviate the interference from biological sample background with high selectivity and sensitivity.

关 键 词：镧系离子 有机配体 配合物 能量转移 增敏发光 药物检测 

分 类 号：TQ460.7[化学工程—制药化工]