探讨LC-MS技术在快速发现和鉴定药物有关物质及代谢产物中的应用  

A Discussion on Quick Discovery and Identification of Drug-related Substances and Metabolites by LC-MS Method

作　　者：王雷娜[1] 景士云[2] 宋敏[1] 杭太俊[1] 姜红[1] 文红梅[3] 张正行[1] 

机构地区：[1]中国药科大学药物分析教研室,江苏南京210009 [2]哈药集团制药总厂,黑龙江哈尔滨150046 [3]南京中医药大学中医药研究院,江苏南京210029

出　　处：《药学进展》2007年第8期358-363,共6页Progress in Pharmaceutical Sciences

摘　　要：探讨LC-MS技术在快速发现和鉴定药物的微量有关物质及代谢产物中的应用,简述LC-MS技术应用原理,介绍LC-MS技术用于药物有关物质和代谢产物快速发现与鉴定的典型实例。The application of LC-MS method in the quick discovery and identification of trace drug-related substances and metabolites was discussed. The application principle was elucidated briefly. The typical examples in the application were introduced.

关 键 词：LC-MS技术 药物有关物质 代谢产物 发现 鉴定 

分 类 号：TQ460.7[化学工程—制药化工]