痰瘀同治法治疗缺血性中风的Meta分析  

For Ischemic Stroke With CPBST:A Meta-analysis of Randomized Controlled Trials

作　　者：蔡业峰[1] 张佛明[1] 张新春[1] 许越[1] 李伟峰[1] 招远琪[1] 尤劲松[1] 郭建文[1] 黄培新[1] 黄燕[1] 

机构地区：[1]广东省中医院脑血管病中心,广东广州510120

出　　处：《中医药导报》2007年第8期1-4,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技支撑计划重大项目(2006BAI04A02);国家科技十五攻关项目(2004BA721A02;2001BA701A12b);广东省科技厅科技攻关项目(2005B33001019);广东省自然科学基金(06301402)

摘　　要：目的:评价痰瘀同治法治疗缺血性中风的疗效。方法:检索中国期刊全文数据库(CNK I)、中国生物医学文献数据库(CBM)和中文科技期刊全文数据库(维普),并追查所有纳入研究的参考文献。检索年限从1979年至2006年。纳入以痰瘀同治法为主要组方依据的临床随机对照试验(RCT)。文献质量评价采用修改后Jadad量表。提取资料采用卡方检验鉴定研究间异质性,根据检验结果选用固定效应模型或随机效应模型,并对对照组进行亚组分析。结果:纳入9个RCT,纳入文献的质量均较低。疗效评价,治疗组相对于对照组OR值为3.41(95%CI:2.40,4.85);神经功能缺损,治疗组相对于对照组WMD(fixed)值为-5.09(95%CI:-6.46,-3.71)。结论:在常规治疗基础上,以痰瘀同治法为组方依据,加用中药方剂,能有效提高临床疗效,尤其有利于恢复中风所造成的神经功能缺损。Objective：To assess the efficacy of combined phlegm and blood stasis treatment（CPBST） in patients with ischemic stroke. Methods： CNKI, CBM and VIP were searched from 1979 to 2006, and the references of eligible studies were manually screened. Randomized controlled trials placing CPBST as the main basis of prescription were eligible for inclusion. The edited Jadad table was used to assess the quality of literatures. Data was extracted and examined its heterogeneity by Chi - square test. Fixed or random effectmeta - analysis were used to pool the data based on the result of Chi - square test. Subgroup analysis were used in controlled group, CPBST. Results：Nine RCTs were included, but their quality were not good. It was found by meta - analysis that, compared with the controlled groups, the OR value of the treating groups was 3.41 （95% CI： 2.40,4.85） in comprehensive efficacy, the WMD （fixed） value of the treating groups was - 5.09（95% Cl： - 6.46, - 3.71 ） in CPBST, the WMD（random） value of the treating groups was -4.60 （95 % Cl： - 6.54, - 2.66 ） in CPBST, and the WMD （fixed） value of the treating groups was 0.08 （95 % Cl：0. 02, 0.13） in CPBST. Conclusion：Prescription based on CPBST combined with conventional treatment is effective in patients with ischemic stroke, especially in resuming the function of injured nerves.

关 键 词：痰瘀同治法 缺血性中风 META分析 

分 类 号：R255.2[医药卫生—中医内科学]