新型异黄酮类化合物对去势大鼠血脂胆固醇的影响  

Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats

作　　者：陈秀明[1] 艾国平[2] 粟永萍[2] 张丽龙[2] 常青[1] 

机构地区：[1]第三军医大学西南医院妇产科,重庆400038 [2]第三军医大学军事预防医学院防原医学教研室全军复合伤研究所创伤,烧伤与复合伤国家重点实验室,重庆400038

出　　处：《第三军医大学学报》2007年第16期1559-1561,共3页Journal of Third Military Medical University

基　　金：重庆市院士基金(2004BC5006)~~

摘　　要：目的通过观察去势后大鼠的血脂和胆固醇及子宫质量/体质量值的改变,探讨腹腔注入不同剂量的改构异黄酮类化合物(F11)对大鼠的影响。方法3月龄的SD大鼠,分为假手术组、阴性造模组(造模组)、雌二醇组(E2组)、不同浓度的F11组(低、中、高剂量F11组);除假手术组外,其余各组均切除双侧卵巢。各组大鼠每日腹腔注射1次,连续用药10周后股动脉放血处死,取血清测定血总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白;称体质量及子宫质量,计算其比值。结果F11各处理组与造模组比较,大鼠血甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白均有显著变化(P<0.05),而体质量较造模组大鼠下降,子宫质量增加。结论改构后的异黄酮类化合物(F11)具有雌激素活性,可以影响血脂及胆固醇,控制体质量,轻微改善阴道及子宫萎缩。Objective To investigate the effect of a novel isoflavone compound （F11 ） on the plasma lipid and cholesterol of the ovarectomied rat. Methods Female SD rats at age of 3 months old were randomly divided into 6 groups, that is, sham operation group （Sham）, normal saline group （2 ml/d）, estradiol group （E2, 50 μg · kg^-1· d^-1） , and 3 F11 groups （15, 50, 150 mg · kg^-1 · d^-1）. Besides the Sham group, the ovary of the rats from other groups were resected, and received the injection as above mentioned. All rats were killed 10 weeks later, and their plasma lipid, total cholesterol, LDL, HDL, and body weight and uterine weight were measured. Results The plasma lipid, total cholesterol, LDL, HDL were significantly different in normal saline group and 4 treatment group （P 〈 0.05 ）. Rats of normal saline group had elevated body weight and decreased uterine weight in comparison with sham group. Conclusion The novel compound F11 can decrease plasma lipid of ovarectomied rat, control body weight and resist the change of uterine.

关 键 词：去势法 动物模型 血脂 体质量 

分 类 号：R331.1[医药卫生—人体生理学] R711.75[医药卫生—基础医学]