幽门螺杆菌尿素酶的分子特性  

The Molecular Character of Urease in Helicobacter Pylori

作　　者：谷贵章 宋达峰 顾青 

机构地区：[1]浙江工商大学生物工程系,浙江杭州310035

出　　处：《药物生物技术》2007年第4期291-296,共6页Pharmaceutical Biotechnology

基　　金：国家自然科学基金资助(30300017)

摘　　要：幽门螺杆菌(Helicobacter pylori,Hp)是定植于人胃上皮组织引起胃炎、消化性胃溃疡和胃癌的病原菌。尿素酶是幽门螺杆菌重要的定植因子和抗原。近年来,尿素酶成为医药领域的研究热点。文章对Hp尿素酶结构、抗原表位、生物学功能及依赖于尿素酶的抗酸性机制等研究进展作一综述。Helicobacter pylori （Hp）, an etiologic agent colonizing the gastic mucosa of human beings, is closely associated with chronic gastritis, peptic ulcer and gastric neoplasm. And urease is an important inhabitence factor and antigen of Hp. During the last few years, researches on Hp urease have been being a focus of iatrology and pharmacology. Here, its structure, antigenic eptitopes, biological functions and urease-depended acid resistance mechanisms were summarized.

关 键 词：幽门螺杆菌 尿素酶 抗酸性 生物学功能 抗原表位 

分 类 号：Q556[生物学—生物化学]