葡萄球菌属中交换基因的载体——SCCmec  

Vehicle for gene exchange among staphylococcal species——SCCmec

作　　者：徐振波[1] 石磊[2] 

机构地区：[1]华南理工大学生物科学与工程学院,广州510640 [2]华南理工大学轻工与食品学院,广州510640

出　　处：《中国抗生素杂志》2007年第8期449-453,465,共6页Chinese Journal of Antibiotics

摘　　要：MRSA在世界范围内广泛蔓延,是医院感染最常见的病原菌之一。一种具有移动能力的新型基因元件SCCmec携带mecA基因,并通过位点特异性重组作用整合到葡萄球菌属的染色体上,使金葡菌携带上mecA基因,产生对β-内酰胺类抗生素的耐药作用。SCCmec共分为5种类型和多种亚型,不同类型的SCCmec其基因构件也不同,适应不同环境。I、II和III型SCCmec携带多个耐药基因,其多重耐药的表型适合于医院环境;IV和V型SCCmec一般比较轻便,该类MRSA能获得较快的生长速率,适合于社区环境。在国际上,不同地区或不同环境流行的MRSA有多种类型,可以分为5大组(CC5、CC8、CC22、CC30和CC45)。不同的MR-SA流行株是通过获得不同类型的SCCmec,经过不同途径进化而来的。MRSA has been spread internationally, and is the most common and prevalent pathogen in nosocomial infection. SCCmec, a novel mobile DNA element, is able to be integrated into the chromosome of S. aureus through site specific recombination, making S. aureus carry rnecA mediating resistance to β-lactam antibiotics. There are 5 types and many subtypes of SCCmecs, and different types of SCCmecs adapt to different environment with their different genetic structure. Generally, type Ⅰ, Ⅱ and Ⅲ SCCmecs carry many resistance genes, making them survive under antibiotic pressure in hospital; on the other hand, type Ⅳ and Ⅴ SCCmecs are much smaller and have a faster growth rate, making them more inclined to exist in community. Internationally, prevalent MRSA can be divided into 5 clonal complex （CC5, CC8, CC22, CC30 and CC45）. Different prevalent epidemic-MRSA acquire different types of SCCmecs, and evolve from different directions.

关 键 词：MRSA SCCMEC ccr复合物 mec复合物 

分 类 号：R378[医药卫生—病原生物学]