啶酰菌胺的合成与生物活性研究  

Synthesis and Bioactivity of Fungicide Boscalid

作　　者：迟会伟 李志念[1] 刘长令[1] 

机构地区：[1]沈阳化工研究院,辽宁沈阳110021

出　　处：《精细化工中间体》2007年第4期14-16,共3页Fine Chemical Intermediates

基　　金："十一五"国家科技支撑计划资助项目(2006BAE01A01-2)。

摘　　要：以对氯苯硼酸和邻碘苯胺为原料,经Suzuki偶合制得联苯胺,再与2-氯烟酰氯反应得到目标产物啶酰菌胺,收率71.2%,其结构经核磁共振验证。室内生物活性测定结果表明该化合物具有广谱的杀菌活性,其在25mg/L浓度下对白粉病、灰霉病的防效分别为85%和70%。Fungicide boscalid was prepared by the reaction of 2-chloronicotinoyl chloride with the intermediate biphenyl-2-amine prepared from the starting materials 2-iodinphenylamine and 4-chlorophenyl boric acid via Suzuki reaction, with the yield 71.2%. The structure was confirmed by 1H NMR. The bioasay results of bioactivity test showed that boscalid had a broad-spectrum and good fungicidal activity, and gave respective 85% and 70% control against powdery mildew and grey mold at 25 mg/L.

关 键 词：啶酰菌胺 合成 杀菌活性 

分 类 号：S482.2[农业科学—农药学]