钩吻生物碱成分的研究进展  

Advances in studies on alkaloid constituents of Gelsemium elegans Benth.

作　　者：张琳[1] 赵庆春[1] 李艳[2] 

机构地区：[1]沈阳军区总医院药剂科,辽宁沈阳110016 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2007年第8期515-520,共6页Journal of Shenyang Pharmaceutical University

基　　金：辽宁省博士启动基金(20030410)

摘　　要：目的对钩吻中生物碱成分的研究进展进行综述,为钩吻生物碱成分的进一步研究奠定基础。方法查阅国内外相关文献47篇,从其中化学成分的理化常数、结构式、提取分离方法、药理作用、毒性以及开发前景等方面对钩吻生物碱类成分的研究进展进行综述。结果与结论钩吻中含有生物碱成分44种,主要为吲哚类生物碱;主要提取分离方法为硅胶柱层析和重结晶;钩吻生物碱具有免疫调节、抗肿瘤、镇痛镇静等药理活性;钩吻中的毒性成分也为生物碱类成分,这给广大研究人员带来了严峻的挑战与机遇。Objective To summarize the research progress in the study of alkaloid constituents of C-elsemium elegans Benth. and provide a reference for the further study of alkaloid constituents of Gelsemium elegans Benth. Methods Recently published papers were consulted. Based on the physical and chemical constants, structural formula, methods of extraction, pharmacological action, toxicity and perspective development, this paper summarized the advancement of the alkaloid constituents of Gelsemittm elegans Benth. Results and Conclusions 44 kinds of alkaloids have been reported for C-elsemium elegans, and mainly were indole alka- loids. The methods of isolation include silica gel column chromatography and recrystallization. The alkaloid constituents of Gelsemium elegans Benth. have many pharmacological actions, such as immune adjustment, anti-turnout, analgesic and sedative activities etc. The toxic part of C-elsemium elegans has also bean proved to be alkaloids constituents. It brings acuted challenge and opportunity to researchers.

关 键 词：钩吻 生物碱 

分 类 号：R94[医药卫生—药剂学]