单向灌流模型研究木犀草素对大鼠在体肠的吸收  

Absorption of Luteolin in Single Pass Intestinal Perfusion Model in Rat

作　　者：周萍[1] 蒋惠娣[2] 

机构地区：[1]大理学院药学院分析化学与药物分析教研室,云南大理671000 [2]浙江大学药学院,浙江杭州310058

出　　处：《现代食品与药品杂志》2007年第4期29-32,共4页JOurnal of Modern Food and Pharmaceuticals

摘　　要：目的研究木犀草素对大鼠在体肠的吸收情况。方法运用单向灌流模型并采用HPLC法测定木犀草素在灌流液中的浓度。结果灌流液中木犀草素浓度为2.556、5.112和10.22μg/ml三个浓度时,有效吸收系数(Peff)无显著性差异(P>0.05);木犀草素在肠道内无特定吸收部位,全肠段均有较好吸收。结论灌流液中木犀草素在2.556、5.112和10.22μg/ml三个浓度时,吸收无自身浓度抑制作用,在肠黏膜的转运为被动扩散过程,且无特殊的吸收窗。To study the absorption of luteolin in intestine of rats. Methods In situ single pass intestinal perfusion model was used, and the concentration of luteolin in perfusate was determined by HPLC. Results There were no significant difference （ P 〉 0.05 ） between the value of Peff of luteolin at three concentrations （2. 556,5.112, and 10.22 μg/ml） of luteolin in perfusate ; Luteolin could be well absorbed at all segments of intestine in rats. Conclusion The absorption of luteolin shows the passive diffusion process, and no special absorption window is observed.

关 键 词：木犀草素 在体肠单向灌流模型 HPLC 吸收 

分 类 号：R965[医药卫生—药理学]