新疆地区482例肿瘤人群人类8型疱疹病毒血清流行病学调查及感染危险因素分析  

Epidemiological study on kaposi′s sarcoma asciociated herpasverus among 482 tumur patients in Xinjiang and the risk factor analysis

作　　者：何方平[1] 王星[2] 张跃新[1] 惠艳[3] 林仁勇[2] 卢晓梅[2] 何斌[4] 温浩[2] 

机构地区：[1]新疆医科大学第一附属医院感染性疾病科,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院中心实验室,新疆乌鲁木齐830054 [3]新疆医科大学第一附属医院皮肤科,新疆乌鲁木齐830054 [4]美国芝加哥大学伊利诺医学院免疫与微生物系中心实验室

出　　处：《中国现代医学杂志》2007年第16期1994-1996,2000,共4页China Journal of Modern Medicine

基　　金：新疆维吾尔自治区自然科学基金项目支持;项目编号200421122

摘　　要：目的对新疆地区肿瘤人群人类8型疱疹病毒流行状况做初步的分子流行病学调查并分析感染危险因素。方法对新疆2所三级甲等医院住院维吾尔族和汉族肿瘤患者进行随机采血和问卷调查及病历记录,采用本实验室建立的组合抗原ELISA方法对样本进行血清特异性抗体的流行病学调查,采用Logistic多元回归分析新疆地区KSHV感染的危险因素。结果482例肿瘤患者血清中,122例血清呈现阳性反应,阳性率25.3%。其中维吾尔族患者阳性率24.8%汉族患者阳性率26.4%。两民族间HHV-8感染率差异无显著性。年龄是KSHV感染的危险因素(P<0.05),民族、性别及输血史等因素与HHV-8感染无相关性。结论血清流行病学调查显示新疆地区为HHV-8高流行区。其流行分布无民族、性别差别,HHV-8感染率随年龄增加而增长。[ Objective] To understand the current epidemic situation and risk factors of kaposi＇s sarcoma asciociated herpasverus （KSHV） prevalence in Xinjiang. [Methods] randomly asked tumur patients hospitalized in two biggest hospitals in Xinjiang, collected serum and questionnaires, using an enzyme-linked immunosorbent assay （ELISA） basing on KSHV of ORF 73c, ORFK8.1, ORF 65 encoded proteins as combined-antigen-ELISA which was established in our lab, for KSHV seroepidemic investigation in Xinjiang. Logistic analysis was used to access the KSHV infection risk factors. [Results] The presence antibodies of KSHV were 25.3%（122/482）. Logistic regression analysis showed age was a risk factor for KSHV infection in Xinjiang. Enthinic, gender, blood transfusion were not risk factors for KSHV infection. [Conclusion] The present study indicated that Xinjiang may be high KSHV prevalence area among general population, KSHV infection rate increasing signifisently with the age.

关 键 词：人类8型疱疹病毒 血清流行病学调查 卡波西肉瘤 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]