大剂量阿托品联合三磷酸胞苷二钠救治重度有机磷中毒的临床价值  

Clinic value of large dose atropine combining with CTP to treat severe organophosphorus pesticides poisoning

作　　者：张兆芳 王靖飞 

机构地区：[1]浙江省岱山县第二人民医院药剂科,316281 [2]浙江省岱山县第二人民医院内科,316281

出　　处：《中国基层医药》2007年第7期1119-1120,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨阿托品联合三磷酸胞苷二钠(CTP)救治重度急性有机磷中毒(AOPP)的疗效和临床价值。方法 68例重度 AOPP 患者分成研究组36例,对照组32例。前者采用大剂量阿托品联合 CTP 治疗,后者单纯使用大剂量阿托品治疗。观察两组患者机械通气时间、中间综合征(IMS)和迟发性周围神经病变(OPIDP)发生率。结果研究组机械通气时间(291.8±73.5)h,迟发性周围神经病变2例,与对照组比较差异有统计学意义(P<0.01)。结论阿托品联合 CTP 治疗重度 AOPP 能有效缩短机械通气时间、降低OPIDP 的发生率,有重要的临床应用价值。Objective To explore the effect and clinic value of atropine combining with ATP to treat AOPP. Methods 68 cases of severe AOPP were divided into research group,36 cases,treated with large dose atropine combined with CTP, and control group,32 cases, treated only with large dose atropine. Mechanic ventilation time inter me diote syndrome（IMS） rate and OPIDP rate of two groups were observed and analysed. Results Mechanic ventilation time of research group was （291.8 ± 73.5 ）h, 2 cases with OPIDP, which had a significant difference compared with control group（P 〈 0.01 ）. Conclusion Atropine combining with CTP to treat severe AOPP has important clinic value,which can reduce mechanic ventilation time,lower occurance of OPIDP.

关 键 词：杀虫药 有机磷/中毒 呼吸 人工 阿托品 肌苷三磷酸 

分 类 号：R595.4[医药卫生—内科学]