抗环瓜氨酸肽抗体 抗角蛋白抗体在类风湿关节炎中的临床意义  

The Diagnostic Value of Anti-cyclic Citrullinated Pepetide Antibody and Anti-keratin Antibody in Patients with Rheumatoid Arthritis

作　　者：王丹彤[1] 陈亮[1] 王耀荣[1] 

机构地区：[1]内蒙古医学院第三附属医院血液风湿内科,内蒙古包头014010

出　　处：《内蒙古医学杂志》2007年第7期797-798,共2页Inner Mongolia Medical Journal

摘　　要：目的:检测抗环瓜氨酸肽抗体(CCP)、抗角蛋白抗体(AKA)在类风湿关节炎(RA)中阳性率及临床意义。方法:用ELASI法检测抗CCP抗体,RA组62例,非RA组53例,用间接免疫荧光法检测AKA,RA组34例,非RA组21例,比较抗CCP抗体AKA与RF相关性。结果:64例RA病人中,抗CCP抗体阳性率为51.6%,非RA组阳性率为5.7%;AKA抗体在34例RA中阳性率29.4%,非RA组阳性率4.76%;抗CCP抗体对RA的敏感性特异性分别为51.6%和95.2%。AKA对RA的敏感性和特异性分别为29.4%和91.8%。结论:抗CCP抗体、AKA对RA有良好的敏感性和特异性,联合检测抗CCP抗体、AKA、RF可提高早期RA的诊断。Objective：To explore the diagnostic value of anti- cyclic citrullinated peptide （CCP） antibody and anti - keratin antibody （AKA） in pati ents with rheumatoid arthritis （RA）. Methods： The anti - ccp was detected by ELISA in 62 RA and 53 non- RA , The AKA was detected by IFA in 34 RA and 21 non - RA to compare the correclation among the anti - ccp and AKA, RF. Results： sixty two （51.6 % ） RA sera and （5.7 % ） non - RA were found to be anti - ccp antibody positive by ELISA, thrity four （29.4 % ） RA sera and nono - RA were found to be AKA positive by IFA. The sensitivity and specificity of anti - ccp antibody was 51.6 %, 95.2 % respectively. The sensitivity and specificity of AKA was 29.4 %, 4.76 % respectively. Conclusions：anti - ccp antibody and AKA presents a reasonable sensitivity with high specificity to RA and it is valuble to RA diagnosis.

关 键 词：抗环瓜氨酸肽抗体 抗角蛋白抗体 类风湿关节炎 

分 类 号：R446.61[医药卫生—诊断学] R593.22[医药卫生—临床医学]