猪胰岛素样生长因子I基因表达与调控的研究进展  

Expression and Regulation of the Pig Insulin-like Growth Factor-IGene

作　　者：肖书奇[1] 李爽[1] 张嘉保[1] 任文陟[1] 刘保国[2] 赵志辉[1] 赵中利[1] 张树敏[3] 

机构地区：[1]吉林大学农学部实验动物中心,吉林长春130062 [2]河南科技学院动物科学学院,河南新乡453003 [3]吉林省农业科学院畜牧分院,吉林公主岭136100

出　　处：《家畜生态学报》2007年第4期90-92,共3页Journal of Domestic Animal Ecology

基　　金：国家振兴东北老工业基地科技攻关项目(2004BA907A22)资助

摘　　要：胰岛素样生长因子-I(I nsulin-like growth factor-I,I GF-I)是机体生长、发育和代谢的一个重要调控因子,同时也是生长激素(growth hormone,GH)启动生长活性的主要介导者。血液中的I GF-I主要来源于肝脏,以内分泌的形式作用于其他组织;许多肝外组织也能合成I GF-I,其主要以自分泌或旁分泌的形式发挥作用。多种因素调控其表达。本文就猪I GF-I的表达与调控方面的最新研究进展进行一综述。Insulin-like growth factor-Ⅰ（IGF-Ⅰ） is an important regulator of growth, development, metatabolism, and is the primary mediator of the growth-promoting activity of growth hormone（GH） in mammals. The primary source of IGF-Ⅰ is the liver, from which IGF-Ⅰ is released into the blood and acts in an endocrine mode on other tissues. IGF-Ⅰ is also synthesized in many extrhepatic tissues, where it functions in an autocrine or paracrine manner. IGF-Ⅰ gene expression is controlled by many factors. This article reviewed the latest research progress of expression and regulation of the pig IGF-Ⅰ gene.

关 键 词：猪 胰岛素样生长因子-Ⅰ 表达 调控 

分 类 号：S811.5[农业科学—畜牧学]