5-辛酰基水杨酸的合成  

Synthesis of 5-n-Octanoylsalicylic Acid

作　　者：吴丽颖[1] 吴振刚[1] 

机构地区：[1]华北煤炭医学院药学系唐山市新药基础研究重点实验室,河北唐山063000

出　　处：《香料香精化妆品》2007年第4期17-18,共2页Flavour Fragrance Cosmetics

摘　　要：以水杨酸甲酯和正辛酸为起始原料,先进行傅克反应再碱水解得到5-辛酰基水杨酸。经1H-NMR、IR确证目标产物结构,总收率70.5%。该路线原料廉价易得,反应条件温和,操作过程简便,适合工业生产。To prepare 5 n octanoylsalicylic acid and simplify the synthetic operation, the target compound was synthesized with methyl salicylate and n-caprylic acid as the starting materials through Friedel-Crafts reaction and hydrolysis with sodium hydroxide. The desired product was obtained in total yield of 70.5% and its structure was confirmed hy ^1H-NMR and IR. In this simplified route, the overall cost is low and the reaction condition is mild, so it is suitable for the industrial manufacture.

关 键 词：LHA 水杨酸 正辛酸 傅克反应 水杨酸甲酯 

分 类 号：TQ245.1[化学工程—有机化工]