心电图在家兔急性心肌梗死诊断中的应用  

Application of electrocardiogram in diagnosing acute myocardial infarction in rabbits

作　　者：杨国勋[1] 刘唐威[1] 钟国强[1] 李金轶[1] 

机构地区：[1]广西医科大学第一附属医院心血管病研究所,南宁市530021

出　　处：《广西医学》2007年第8期1135-1138,共4页Guangxi Medical Journal

基　　金：广西自然科学基金资助课题(桂科回0448014);广西医疗卫生科研课题(桂卫重200301)

摘　　要：目的探讨心电图各指标对家兔急性心肌梗死(AMI)的诊断价值。方法40只兔随机分为AMI组和假手术组(SH组),采用开胸结扎冠状动脉左前降支的方法建立AMI模型,检测术前、术后10min内和术后6周心电图的变化,6周后取出心脏作病理检查。结果两组术前心电图均正常。AMI组术后10min内心电图胸导联ST段较术前明显抬高(P<0.01),ST段抬高(>0.2mV)对AMI诊断的灵敏度为84.6%(11/13),特异度为100%(2/2)。和术前比较,两组术后均出现心率减慢、胸导联R波振幅降低(P<0.01),但两组间比较差异无统计学意义(P>0.05)。术后6周心电图胸导联显示病理性Q波只见于大体病理可见较明显的梗死瘢痕形成的兔中。结论心电图ST段抬高和病理性Q波对家兔AMI具有重要的诊断价值。Objective To investigate diagnostic value of electrocardiogram in determining acute myocardial infarction （AMI） in rabbits. Methods Forty rabbits were divided into two groups randomly,AMI group （n=20） and sham-operation group（SH group,n =20）. Establishing AMI models by ligating left anterior descending（LAD） branch of coronary artery. Before operation, 10 minutes and 6 weeks after ligating LAD, electrocardiogram （ECG） changes were investigated, respectively. The pathological changes were observed 6 weeks after operation. Results Preoperative electrocardiogram was normal in two groups. Compared with preoperation period, a significant raise of ST segment was observed 10 minutes after ligating LAD in AMI group （ P 〈 0. 01 ）. The sensitivity and specificity of ST segment elevating （ 〉0.2 mV） for diagnosing AMI were 84.6% （11/13 ） and 100% （2/2）, respectively. Compared with preoperation period, heart rates slow significantly and R waves decreased 10 minutes after operation in two groups （ P 〈 0.01 ）, but there were no significant difference in heart rates and R waves between two groups （ P 〉 0.05 ）. 6 weeks after ligation, pathologic Q wave was only seen in rabbits which were formed gross M1. Conclusion ST segment elevating （ 〉0.2 mV） and pathologic Q wave are important for the diagnosis of AMI of rabbits.

关 键 词：心肌梗死 心电图 诊断 兔 

分 类 号：R542.22[医药卫生—心血管疾病]