壳寡糖对高脂血症小鼠降血脂及肝脏保护的作用  

Studies on the effect of chito oligosaccharide on reducing cipid and protecting liver of chito oligosaccharide in hyperlipidemia mice

作　　者：申杰[1] 叶希韵[1] 沈菊[1] 金百胜[1] 王耀发[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《西北农林科技大学学报（自然科学版）》2007年第9期35-38,44,共5页Journal of Northwest A&F University(Natural Science Edition)

基　　金：农业部"948"项目(2006-G28)

摘　　要：通过建立高脂血症小鼠模型来研究壳寡糖对小鼠降血脂及肝脏保护的作用。将昆明种小鼠分为正常组、高脂血症模型组、壳寡糖组和脂必妥对照组,喂养7周后,测定血清中总胆固醇(TC)、高密度脂蛋白胆固醇脂(HDL-C)的含量,丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)活性以及肝脏中丙二醛(MDA)、总巯基(T-SH)、非蛋白结合巯基(NP-SH)和蛋白结合巯基(PB-SH)的含量。结果表明,壳寡糖使高脂血症小鼠血清中TC含量、ALT和AST活性显著降低,HDL-C/TC显著升高,显著提高了肝脏中T-SH的含量,降低了肝脏中的MDA含量。说明壳寡糖具有明显降血脂和保护肝脏的作用。To investigate the prevention effect of chito oligosaccharide on hyperlipidemia in mice and protective effect on liver of chito oligosaccharide in mice,40 Kunming mice are divided into four groups randomly.controlled group（N）, high lipid group（L）,chito oligosaccharide group（C） and positive drug group （zhibituo） （P）.The levels of TC,HDL-C,ALT and AST in serum and the contents of T-SH,NP-SH and PB-SH,MDA in livers are determined in all groups after 7 weeks. Compared with group L,there are declines of TC,ALT,AST in serum and MDA in livers. There are increases of the ratio of HDL-C to TC in serum and T-SH in livers. The results show that chito oligosaccharide decrease the level of lipid in serum and have a protective effect on liver in mice.

关 键 词：壳寡糖 高脂血症 降血脂作用 护肝作用 小鼠 

分 类 号：R965[医药卫生—药理学] S865.13[医药卫生—药学]