尼美舒利联合阿莫西林治疗急性化脓性扁桃体炎的疗效观察  

Evaluation on the Effect of the Combined Use of Nimesulide Dispersible Tablets with Amoxicillin on the Treatment of Acute Suppurative Tonsillitis

作　　者：叶林峰[1] 吴曙辉[1] 周绪红[1] 江孝清[1] 

机构地区：[1]武汉大学中南医院耳鼻咽喉科,430071

出　　处：《医药导报》2007年第9期1026-1027,共2页Herald of Medicine

摘　　要：目的探讨尼美舒利联合阿莫西林治疗急性化脓性扁桃体炎的疗效及安全性。方法急性扁桃体炎患者100例随机分成两组。治疗组52例,给予尼美舒利分散片100 mg,bid;阿莫西林胶囊500 mg,tid,po。对照组48例,给予阿莫西林胶囊500 mg,tid,po。7 d为1个疗程,观察体温开始下降时间、体温恢复正常时间、扁桃体充血消失时间、扁桃体脓性分泌物消失时间、临床症状消失时间,并根据以上观察指标改善情况比较两组的疗效。结果治疗组和对照组体温开始下降时间平均分别为1.0和1.5 d,体温恢复正常时间平均分别为1.0和2.5 d,扁桃体充血消失时间平均分别为1.5和3.5 d,扁桃体脓性分泌物消失时间平均分别为3.0和5.5 d,临床症状消失时间平均分别为3.5和6.0 d。痊愈率分别为78.8%和62.5%,总有效率分别为98.1%和79.2%。结论尼美舒利联合阿莫西林治疗急性化脓性扁桃体炎比单纯使用阿莫西林疗效好。Objective To investigate the therapeutic efficacy and safety of the combined use of nimesulide dispersible tablets with amoxicillin on the treatment of acute suppurative tonsillitis. Methods One hundred patients with acute suppurative tonsillitis were divided randomly into two groups： the combination treatment group was treated with nimesulide dispersible tablets 100 mg twice a day and amoxicillin sodium 500 mg three times a day for 7 d; the control group was treated with amoxicillin sodium 500 mg three times a day for 7 d. The beginning time of body temperature falling, the recovery time of body temperature, the disappearance time of tonsilar congestion, the disappearance time of tonsilar purulent secretion and the disappearance time of clinical symptoms were observed, with the efficacy of two groups evaluated by these indexes. Results The results of the combination treatment group and the control group were as follows： the average beginning time of body temperature falling was 1.0 d and 1.5 d , respectively; the average recovery time of body temperature was 1.0 d and 2.5 d, respectively; the average disappearance time of tonsilar congestion was 1.5 d and 3.5 d , respectively ; the average disappearance time of tonsilar purulent secretion was 3.0 d and 5.0 d , respectively ; the average disappearance time of clinical symptoms was 3.5 d and 6.0 d , respectively; the recovery rates were 78.8% and 62.5% , respectively; the total response rates were 98. 1% and 79.2% , respectively. Conclusion The efficacy of the combined use of nimesulide dispersible tablets and amoxicillin sodium on the treatment of acute suppurative tonsillitis is better and faster than that of the use of amoxicillin sodium alone.

关 键 词：尼美舒利 阿莫西林 扁桃体炎 

分 类 号：R971.1[医药卫生—药品] R766.18[医药卫生—药学]