复方盐酸利多卡因栓的制备与体外释放度考察  

Preparation and Study on Drug Release of Compound Lidocaine Hydrochloride Suppository in Vitro

作　　者：黄丽丽[1] 费路华[1] 曾凡波[1] 程波[1] 张丽敏[1] 吕白桦[1] 

机构地区：[1]华中科技大学同济医学院药学院,武汉430030

出　　处：《医药导报》2007年第9期1070-1071,共2页Herald of Medicine

摘　　要：目的研究复方盐酸利多卡因栓剂的制备工艺。方法以盐酸利多卡因、氧化锌为主药,半合成脂肪酸甘油脂(36型)、吐温-80为基质,通过加入不同剂量的表面活性剂吐温-80,考察吐温-80含量对药物释放的影响。结果随着吐温-80用量增加,栓剂中释药加快,当吐温-80含量为1%时,在60 m in内>90%药物释放。结论吐温-80能加快药物从栓剂中释放,含量为1%时栓剂能达到设计要求。Objective To investigate the preparation technology of compound lidocaine hydrochloride suppository. Methods With lidocaine hydrochloride and zinc oxide as the chief drug, semi-synthetic glyceride as the matrix, surfactant Tween-80s of different doses were employed to study the correlation between the drug release rates from suppositories and the concentrations of Tween-80. Results Drug was released more rapidly from suppositories accompanying an increasing dose of Tween-80. When the concentration of Tween-80reached 1%, drug release could reach above 90% in 60 min. Conclusion Tween-80 can increase the release rate of drug from suppositories. The suppositories with 1% Tween-80 can meet the design requirements.

关 键 词：利多卡因 盐酸 氧化锌 栓剂 释放度 

分 类 号：R971.2[医药卫生—药品] TQ460.6[医药卫生—药学]