切除雄鼠球海绵体肌与不育关系的探讨  

Study the relationship the amputation of male wistar rat’s bulbocavernosus and infertility

作　　者：陈宗平[1] 赵泽驹[1] 吴涛[1] 李本根[1] 付逆[1] 陆立[1] 邱兆雨[1] 王琦[1] 陈秀婷[1] 周超[1] 

机构地区：[1]遵义医学院附属医院泌尿外科,563003

出　　处：《贵州医药》2007年第8期688-689,共2页Guizhou Medical Journal

摘　　要：目的探讨球海绵体肌对勃起功能的影响及在勃起机制中的作用。方法选用生殖期雄性大白鼠30只,随机分为切除球海绵体肌组(20只),切断双侧坐骨海绵体肌组(5只),非手术组(5只)。手术后1周选用育龄期雌性大白鼠30只,随机与上述三组一一配对饲养,观察2月,了解三组配对雌鼠受孕情况。结果切除球海绵体肌组,雄鼠死亡4只,雌鼠17只受孕,受孕率89.6%。切断双侧坐骨海绵体肌组,雄鼠死亡1只,雌鼠5只均未受孕,受孕率0。非手术组5只雌鼠均受孕,受孕率100%。切除球海绵体肌组与切断双侧坐骨海绵体肌组雌鼠受孕情况比较差异有非常显著性(P<0.001),与非手术组比较无统计学意义(P>0.05)。结论切除雄鼠球海绵体肌不会导致勃起功能障碍及不育,球海绵体肌在勃起机制中不起作用。Objective To discuss the relation of bulbocavernosus with erectile function and the role of bulbocavernosus in erection. Methods 30 male wistar rats in procreative period were selected and divided into 3 groups randomly .Amputation of bulbocavernosus group（20）, section both sides of ischiocavernosus group（5） and non-operation group（5）. One week after operations , 30 female wistar rats in procreative period were selected to match them one -to-one at random. After 2 months of breeding, pregnancy of these matching female wistar rats were recorded. Results 4 died in first group , and 17 female rats were pregnancy （89. 6%）. in the second group ,1 died ,all of the 5 female rat were not pregnancy（0）. All of the 5 matching female rats in the non-operation group got pregnant （100 % ）. There was distinct discrepancy between the amputation bulbocavernosus group and section of both sides of ischiocavernosus group（P〈0. 001） . While no distinct discrepancy between the amputation bulbocavernosus group and the non-operation group（P〉0. 05）. Conclusion Amputation of bulbocavernosus will not lead to erectile dysfunction and infertility, bulbocavernosus is dispensable in erection.

关 键 词：球海绵体肌 雄鼠 不育 勃起机制 勃起功能障碍 

分 类 号：R69[医药卫生—泌尿科学]