53例儿童中枢神经系统感染血清及脑脊液降钙素原检测的临床意义探讨  

Clinic value of detecting procalcitonin in blood serum and cerebrospinal fluid of 53 children with nerve centre infection

作　　者：潘丹丹[1] 孙明明[1] 越敏[1] 刘庭英[1] 谢迪 

机构地区：[1]贵阳医学院附属医院儿科,550004 [2]贵阳市第五人民医院传染科,550004

出　　处：《贵州医药》2007年第8期692-694,共3页Guizhou Medical Journal

基　　金：贵州省卫生厅科技计划项目资助2005-138

摘　　要：目的探讨钙素原(PCT)检测在儿童中枢神经系统(CNS)感染中的临床应用价值。方法采用半定量固相免疫测定法测定53例CNS感染患儿血清和脑脊液(CSF)PCT,20例非感染性疾病作为对照。结果化脑组血清PCT阳性率(100%)明显高于病脑组(8.0%)、结脑组(0),差异有统计学意义;化脑组脑脊液PCT阳性率76.9%,病脑组及结脑组阳性率均为0;化脑组血清PCT与脑脊液PCT之间的直线相关关系有统计学意义,且呈正向变化关系。血清PCT检测诊断化脑的敏感性、特异性、阳性预测值、阴性预测值均达到100%(以PCT≥2.0ng/ml为阈值),脑脊液PCT检测以上各值分别为76.9%、100%、100%、95.2%(以PCT≥0.5ng/ml为阈值)。结论血清及脑脊液PCT检测可作为化脑鉴别于病脑及结脑的一项灵敏指标,可用于辅助指导儿童CNS感染性疾病的早期诊治。Objective To explore the clinic value of detecting procalcitonin （PCT） in 53 children with nerve centre infection. Methods Semi quantitative solid- immunoassay was conducted to detect PCT in serum and cerebrospinal fluid （CSF） of 53 children with nerve centre infection, other 20 children without infection diseases were acted as control group. Results The positive rate of serum PCT in purulent meningitis group （100%） was obviously higher than that in viral encephalitis group （8%） and in tubercular meningitis group （0）, the difference was statistically significant. The positive rate of CSF PCT in purulent meningitis group was 76. 9%, while it was 0 in other two experimental groups. A linear correlation existed between the serum PCT and CSF PCT in purulent meningitis group, and it showed positive change relations. The sensitivity, specificity, positive predictive value and negative predictive value of using serum PCT test to diagnose purulent meningitis all reached 100%. They were 79. 6%, 100%, 100%, 95. 2% respectively while using CSF PCT test. Conclusion PCT could be proposed as one of an important differential marker between purulent meningitis and viral encephalitis or tubercular meningitis.

关 键 词：降钙素原 中枢感染 血清 脑脊液 儿童 

分 类 号：R729[医药卫生—儿科]