实验性犬侧颅底骨缺损修复材料的研究  

Histological study of experimental reconstructive materials for lateral skull base and dural defects in dogs

作　　者：时利[1,2,3] 吴彦桥[1,2,3] 时文杰 邹静[1,2,3] 徐铮 修贺明 成继民[1,2,3] 尚耀东 彭子成[1,2,3] 毕爱芳 

机构地区：[1]解放军254医院耳鼻咽喉-颅底外科 [2]解放军白求恩国际和平医院 [3]天津医科大学

出　　处：《中华耳鼻咽喉科杂志》1997年第2期95-98,共4页Chinese Journal of Otorhinolaryngology

摘　　要：为达到修复颅底骨和硬脑膜缺损的目的，通过手术造成狗侧颅底骨及硬脑膜大面积缺损模型，利用自体阔筋膜或与细胞生长促进因子——骨形成蛋白（ｂｏｎｅｍｏｒｐｈｏｇｅｎｔｉｃｐｒｏｔｅｉｎ，ＢＭＰ）进行修复。观察移植后不同时期所修复组织的成活及成骨的组织学变化情况。探讨了阔筋膜修复硬脑膜后组织学变化，证实生物膜与骨形成蛋白是一种理想的颅底缺损修复材料，为临床修复硬脑膜、颅底缺损等提供了参考。In order to observe the reconstructive effects of fascia lata,superficial fascia and bone morphogentic protein (BMP)in skull base surgery, a lateral skull base bone and dural defect model in dogs was established.Fascia was selected alone or combined with BMP as repairing materials and BMP was evaluated in reconstructing large cranial defect model .Forty dogs underwent a 3.0×4.0 cm full-thickness excision of the parietal bone were divided into different groups of five dogs each ,and were reconstructed by ①fascia lata; ②fascia lata plus BMP; ③nonreconstructed controls; ④fascia lata plus BMP and exposed .The implants were harvested at 2～15 weeks and examined histologically .The new bone was found in the BMP. Implants treated and untreated were quite different. The unreconstructed controls demonstrated only a bridge of fibrovasular connective tissue. BMP are defined as osteoinductive by their ability to produce bone formation by stimulating mesenchymal cells to tranform into bone producing osteo blasts.The results suggested the combination of BMP and reconstructive material in the treatment of bone defects.

关 键 词：颅骨缺损 外科手术 修复 骨形成蛋白 

分 类 号：R683.505[医药卫生—骨科学]