心内直视术后危重病儿钙转运异常的研究  

Abnormality of cellular calcium transport in critically ill children after open heart surgery

作　　者：王涛[1] 张善通[1] 李生德 汤顺荣[1] 

机构地区：[1]上海医科大学儿科医院心血管中心

出　　处：《中华麻醉学杂志》1997年第1期4-6,共3页Chinese Journal of Anesthesiology

摘　　要：目的：为了研究心内直视术后危重病儿细胞钙转运机制，指导术后正确的监护处理。方法：对１３例存活与７例死亡病儿血清离子钙浓度、红细胞钙含量、Ｃａ２＋，Ｍｇ２＋－ＡＴＰａｓｅ及Ｎａ＋，Ｋ＋－ＡＴＰａｓｅ活性进行测定。结果：术前两组上述各项指标均无差异（Ｐ＞０．０５）；术后死亡组血清离子钙浓度进行性下降，ＡＴＰ酶活性降低，红细胞钙含量持续升高。而存活组血清离子钙浓度在术后２小时红细胞钙含量与ＡＴＰ酶活性在术后１２小时恢复至术前水平，两组差异显著（Ｐ＜０．０１）。结论：心内直视手术后危重病儿存在严重的细胞钙转运异常，与器官功能衰竭及死亡有关。Objective:The corpuscular calcium transport in critically ill children after open heart surgery was studied.Methods:We observed the serum ionized calcium concentration,erythrocyte calcium content and activities of erythrocyte membrane Ca 2+ ,Mg 2+ ATPase,Na +,K + ATPase in 13 surviving (Group S) and 7 death(Group D) patients.Results:There were no significant difference before operation between two groups(P>0 05).After operation,in Group D the serum ionized calcium concentration and Ca 2+ ,Mg 2+ ATPase,Na +,K + ATPase activities were constantly reduced,erythrocyte calcium content was increased (P<0 01),but in Group S the serum ionized calcium concentration in 2 hours and the erythrocyte calcium content,Ca 2+ ,Mg 2+ ATPase and Na +,K + ATPase activities were all returned to baseline at 12 hours postoperation.Conclusion:Critically ill children after open heart surgery exist serious abnormality of cellular calcium transport,which is related to organ dysfunction and death.

关 键 词：钙转运异常 心脏手术 心内直视术 儿童 

分 类 号：R654.2[医药卫生—外科学]