丹参酸乙对四氯化碳体外损伤原代培养大鼠肝细胞的直接保护作用  

Direct Protection of Injured Primary Cultured Hepatocytes of Rats Treated with Carbon Tetrachloride by Salvianic Acid B

作　　者：刘平[1] 刘乃明[1] 徐列明[1] 胡义杨[1] 季光[1] 刘成[1] 

机构地区：[1]上海市中医药研究院肝病研究中心

出　　处：《中国中药杂志》1997年第5期303-305,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：四氯化碳体外损伤原代培养大鼠肝细胞的［３Ｈ］胸腺嘧啶核苷掺入量显著降低，培养液中ＡＬＴ活性显著增高；丹参酸乙（ＳＡ－Ｂ）能有效地阻抑细胞的这种病理变化，均以１０－６ｍｏｌ／Ｌ浓度的ＳＡ－Ｂ的作用最佳。The incorporation of thymidine obviously tends to decrease in the primary cultured hepatocytes of rats when the cells are treated with carbon tetrachloride. Meanwhile the activity of ALT markedly increases in the medium. But these pathologic alterations are inhibited by Salvianic acid B(SA B)and the effect of 10 -6 mol/L SA B is the best.

关 键 词：丹参 丹参酸乙 肝细胞损伤 

分 类 号：R285.6[医药卫生—中药学]