养肝澳平合剂治疗慢性乙型肝炎的临床及实验研究  

Clinical and Experimental Study on Treatment of Chronic Hepatitis B with Yanggan Aoping Mixture

作　　者：俞荣青[1] 毕建军[1] 王前山[1] 薛学坤[1] 潘雪飞 吴春东 常洁 黄国健[1] 

机构地区：[1]江苏省中医院

出　　处：《中国中西医结合杂志》1997年第3期155-158,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的：观察养肝澳平合剂治疗慢性乙型肝炎的疗效。方法：慢性肝炎患者采用养肝澳平合剂治疗，观察近期、远期疗效及血清乙肝病毒标志物变化。实验研究：养肝澳平合剂大鼠肝损伤实验及对树感染人乙肝病毒、鸭感染鸭乙型肝炎病毒的影响。结果：治疗组１５２例慢性乙型肝炎中，慢性迁延型肝炎７９例显效率６０．７６％，随访４０例远期显效率７０．００％；慢性活动性肝炎７３例显效率６０．２７％，随访３２例远期显效率６２．５０％。治疗组ＨＢｅＡｇ阳性１１９例，阴转率７１．４３％；对照组ＨＢｅＡｇ阳性８９例，阴转率４４．９４％；两组比较差异显著（Ｐ＜０．０１）。实验研究结果证实：养肝澳平合剂对树感染人乙肝病毒标志物阴转率增高，感染鸭血中鸭乙型肝炎病毒（ＤＨＢＶ）ＤＮＡ被抑制，分别与对照组比较，差别有显著性意义。结论：养肝澳平合剂对慢性乙型肝炎有治疗作用，对乙肝病毒标志物有转阴作用。To assess the efficacy of Yanggan Aoping Mixture(YGAPM)in treating hepatitis B.Methods:Patients suffered from chronic hepatitis B were treated with YGAPM. Observe their shortand long-term efficacy and the change of serum hepatitis B virus marker. In experiment, the effect of YGAPM in treating rat's liver injury as well as HBV-infected tree shrew and duck HBV-infected ducks was observed. Results :In 79 cases of chronic persistant hepatitis, the markedly effective rate was 60. 76 %,and follow-up studies on 40 cases,the futher rasied to 70. 00 %. In 73 cases of chronic active hepatitis, the markedly effective rate was 60. 27%, and further raised to 62. 50% in 32 follow-up cases. In the treatment group , 85 (71. 43 % )of the 119 cases with HBeAg-positive turned to negative. Whereas in the control group,only 40 (44. 94 % )of 89 HBeAg-positive cases turned to negative, P<0. 01 . Results of experimental study showed that negative conversion rate of tree shrew infected with HBV marker was raised,while infected duck blood with duck HBV DNA was inhibited.Those compared with the control group separately, the difference was remarkably significant. Conclusions: YGAPM is an effective drug in treating chronic hepatitis B,and it could effectively negative convert the HBV marker.

关 键 词：慢性 乙型肝炎 养肝澳平合剂 中医药疗法 

分 类 号：R259.126.2[医药卫生—中西医结合]