The difference of endothelial adherence between the clinical and commensal strains of Staphylococcus epidermidis  

作　　者：LIN XU LI WANG JIAN PING WANG MIN LI YUAN LU QIAN GAO 

机构地区：[1]Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, P. R. China [2]Institute of Medical Microbiology, Fudan University, Shanghai, P. R. China [3]Center of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China

出　　处：《Journal of Microbiology and Immunology》2007年第1期17-22,共6页中华微生物学和免疫学（英文版）

基　　金：This work was supported by the Chinese National Natural Science Foundation(30670108);Shanghai Municipal Science and Technology Commission(05PJ14025).

摘　　要：Staphylococcus epidermidis is one of the leading pathogens of nosocomial infections. Twenty- eight strains of biofilm-negative Staphylococcus epidermidis, of which thirteen strains considered as the clinical strains were isolated from catheters, blood and urine of patients in Huashan Hospital （Shanghai, China） and fifteen strains considered as commensal strains were isolated from the skin of healthy students who had no contact with hospitals in recent half year, were investigated for the adherence to human umbilical vein endothelial cell line ECV304 and human cervical adenocarcinoma cell line Hela, respectively. Our results showed that the clinical strains were much more adhesive to both cells than commensal ones. The endothelial adherence may be a virulence factor associated with this bacterial pathogenesis.Staphylococcus epidermidis is one of the leading pathogens of nosocomial infections.Twenty- eight strains of biofilm-negative Staphylococcus epidermidis,of which thirteen strains considered as the clinical strains were isolated from catheters,blood and urine of patients in Huashan Hospital(Shang- hai,China)and fifteen strains considered as commensal strains were isolated from the skin of healthy students who had no contact with hospitals in recent half year,were investigated for the adherence to human umbilical vein endothelial cell line ECV304 and human cervical adenocareinoma cell line Hela, respectively.Our results showed that the clinical strains were much more adhesive to both cells than commensal ones.The endothelial adherence may be a virulence factor associated with this bacterial pathogenesis.

关 键 词：Staphylococcus epidermidis Endothelial adherence Biofilm 

分 类 号：R392.3[医药卫生—免疫学]