利福霉素高产菌株的诱变选育  

Study on Breeding of Rifamycin Producing High-yield Strain

作　　者：李翠民 

机构地区：[1]漯河南街村药业集团制药有限公司,河南漯河462000

出　　处：《武汉职业技术学院学报》2007年第3期84-85,95,共3页Journal of Wuhan Polytechnic

摘　　要：以利福霉素SV自身耐受性菌株为出发菌株,经HNO2+UV和HNO2+UV+Licl分别复合诱变后,获得两株变异菌株。结果表明:其发酵单位大幅度提高,较出发菌株分别提高了17.8%和15.1%,并且其遗传稳定性较好。the experiment in the paper chooses auto-tolerance strain of Rifamycin SV as starting strain, after compound inductions by HNO2＋UV and HNO2＋UV＋Licl respectively, two mutated strains are rendered. The result shows that its ferment unit gets aggrandized dramatically by 17.8% and 15.1% respectively, and this advantage can pass on consistently.

关 键 词：地中海诺卡氏菌 利福霉素SV 诱变 变异 

分 类 号：R282.71[医药卫生—中药学]