成都地区50岁以上骨质疏松患者QCT骨密度在不同性别及体质量间的差异  

Bone mineral density measured by quantitative computed tomography in osteoporotic patients aged over 50 years in Chengdu:Differences among sex and body mass

作　　者：田景伦 邓和[2] 郑权[3] 何书经 乐小燕[1] 

机构地区：[1]成都市温江区人民医院内分泌科,四川省成都市611130 [2]成都市温江区人民医院放射科,四川省成都市611130 [3]成都市温江区人民医院检验科,四川省成都市611130

出　　处：《中国组织工程研究与临床康复》2007年第36期7275-7277,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:分析成都地区50岁以上骨质疏松患者羟磷灰石定量计算机断层扫描骨密度的变化及部分影响因素。方法:①对象:选择2004-05/2006-02在成都市温江区人民医院内分泌科住院的原发性骨质疏松患者189例。男80例,年龄(69.21±8.87)岁,女109例,年龄(67.14±8.85)岁。②分组:按年龄分为50～59岁,60～69岁,70～79岁,≥80岁4个组,按体质量指数分为<18.5,18.5～23.9,24.0～27.9,≥28.0kg/m2,即消瘦、正常、超重和肥胖4个组。③评估:用国产HK-2000QCT骨矿密度测定校验体模系统测定腰椎L1～3骨密度,分别探讨年龄和体质量指数与QCT骨密度的关系。结果:①男女两组50岁以上骨质疏松患者QCT测定的L1～3骨密度和T值均随年龄增加而逐渐降低,二者与年龄呈直线负相关关系(P<0.01)。②女性患者在60～79岁之间骨密度下降速率与相同年龄男性比较更快。③按体质量指数分组,消瘦组骨密度和T值显著低于正常体质量(P<0.05)和超重组(P<0.01),与肥胖组比较差异无统计学意义(P>0.05)。结论:50岁以上骨质疏松患者骨密度降低随年龄增加而逐渐加重,消瘦患者比正常体质量和超重患者骨密度降低更严重。AIM： To investigate the changes of bone mineral density （BMD） measured by quantitative computed tomography （QCT） in osteoporotic patients aged over 50 years in Chengdu and to explore the influential factors. METHODS： ①189 inpatients with primary osteoporosis were selected from Department of Endocrinology, Wenjiang People＇s Hospital of Chengdu from May 2004 to February 2006, including 80 males aged （69.21±8.87） years and 109 females aged （67.14±8.85） years. They were divided into 4 groups by age： 50-59, 60-69, 70-79, and ≤80 years groups, and by body mass index （BMI）： marasmus group （BMI 〈 18.5 kg/m^2）, normal group （BMI 18.5-23.9 kg/m^2）, overweight group （BMI, 24.0-27.9 kg/m^2） and obesity group （BMI ≤28.0 kg/m2）. ②BMD and T-score of three lumbar vertebrae （L1-3） were determined by HK-2000QCT made in China to explore the association of age and BMI with QCT BMD. RESULTS： ①In osteoporotic patients aged over 50 years, the BMD of L1-3 and T-score were decreased with age; it was a negative linear correlation （P 〈 0.01）. ②The decrease rate of BMD in female patients aged between 60 and 79 years was more obvious compared with that of males at the same age. ③Marasmus group had a significantly decrease trend of BMD and T-score compared with normal group （P 〈 0.05） and overweight group （P 〈 0.01）, but no significant differences were observed compared with obesity group （P〉 0.05）. CONCLUSION： The loss of BMD is accelerated with ageing in osteoporotic patients aged over 50 years and the decrease in marasmus group is more distinct compared with that in normal group and overweight group.

关 键 词：骨质疏松 骨密度 体层摄影术 组织构建 

分 类 号：R681.4[医药卫生—骨科学]