川崎病患儿458例冠状动脉损害危险因素研究  

Analysis of risk factors of coronary artery lesion secondary to Kawasaki disease in Shanxi province

作　　者：李亚蕊[1] 李俊[2] 曾超[2] 王丽红[1] 

机构地区：[1]山西省儿童医院心内科,太原030013 [2]山西医科大学儿科系

出　　处：《中华风湿病学杂志》2007年第9期547-549,共3页Chinese Journal of Rheumatology

摘　　要：目的：探讨川崎病（KD）患儿合并冠状动脉病变（CAL）的危险因素。方法：选择2000—2004年在山西省4个地区的4所医院住院的458例确诊川崎病患儿为研究对象。回顾性分析这些患儿的临床资料,对合并冠状动脉病变组（CAL）和未合并冠状动脉病变组（无CAL）的病例进行组间对照研究,并对影响CAL发生的15种因素进行Logistic回归分析。结果：单因素分析显示：就诊时发热天数、总发热天数、血小板计数（PLT）、红细胞沉降率（ESR）、C反应蛋白（CRP）与CAL的发生密切相关（P〈0.05或P〈0.01）;多因素Logistic回归分析显示：年龄、总发热天数、CRP与KD合并CAL显著独立相关（P〈0.05或P〈0.01）。结论：年龄〈1岁、总发热天数〉10d、CRP增高是KD合并CAL的高危因素。Objective To investigate the risk factors in children with coronary artery lesion （CAL） secondary to Kawasaki disease （KD） in Shanxi province, China. Method Four hundred and fifty-eight patients younger than 18 years with KD hospitalized in four hospitals from January 2000 to December 2004 were included in this study. These 4 hospitals were located at four different regions of Shanxi province. Clinical data of these patients were analyzed retrospectively. All cases with or without CAL were analyzed by case-control study, and Logistic regression analysis of 15 influencial factors of CAL was made. Results Univariate analysis indicated that the duration of fever before hospitalization, the total duration of fever, platelet （PLT） count, erythrocyte sedimentation rate （ESR）, C-reactive protein （CRP） was closely associated with CAL secondary to KD （P〈0.05 or P〈0.01）. Multivariate Logistic regression analysis indicated that age under one year old, the total fever duration （longer than 10 days） and elevated CRP were independently correlated with CAL secondary to KD. Conclusion Younger than one year, the total fever duration （longer than 10 days） and elevated CRP are the high-risk factors of CAL in KD.

关 键 词：黏膜皮肤淋巴结综合征 危险因素 冠状动脉损害 

分 类 号：R686[医药卫生—骨科学]