伊曲康唑和γ-干扰素对裸小鼠、昆明种小鼠外周血IFN-γ、IL-10的影响  

Effect of Itraconazole/IFN-gamma on IFN-gamma and IL-10 in Nude Mice and Mice

作　　者：王志东[1] 廖万清[1] 徐红[1] 陶文照[2] 

机构地区：[1]第二军医大学附属长征医院皮肤科,上海200003 [2]第二军医大学附属长海医院病理科

出　　处：《医学研究杂志》2007年第9期46-49,共4页Journal of Medical Research

摘　　要：目的研究伊曲康唑和γ-干扰素治疗分别感染白念珠菌和新生隐球菌裸小鼠、昆明种小鼠外周血细胞因子IFN-γ、IL-10的改变及其临床意义。方法将白念珠菌和新生隐球菌分别注射入裸小鼠、昆明种小鼠体内,诱导成动物模型。用ELISA法检测IFN-γ和IL-10的水平。结果经过伊曲康唑和γ-干扰素治疗后,其外周血的IFN-γ上升而IL-10下降。结论伊曲康唑和γ-干扰素对真菌感染小鼠免疫功能的调节起着重要作用。Objective To study the effect of itraconazole/IFN - gamma on IFN - γ and IL - 10 in nude mice and mice and clinical significance. Methods Systemic infection of animals that induced by abdominal injection of Candida albicans and Cryptococcus neoformans, Expression of IFN - γ and IL - 10 were detected by enzyme - linked immunosorbent assay （ ELISA）. Results After treated with Itraconazole and IFN - gamma, the levels of IFN - gamma were increased and ones of IL - 10 were decreased significantly. Conclusions Itraconazole and IFN - gamma may play key roles in the immune function of those animals.

关 键 词：Γ-干扰素 白介素-10 白念珠菌 新生隐球菌 伊曲康唑 

分 类 号：R392.12[医药卫生—免疫学]