慢性阻塞性肺病患者血清细胞因子与肺功能相关性研究  

Correlation of serum cytokines level and pulmonary function in patients with chronic obstructive pulmonary disease

作　　者：刘笑然[1] 丁春华[2] 叶琳 谭家庆[2] 

机构地区：[1]海南医学院病理生理教研室,海南海口571101 [2]河北医科大学病理生理教研室,河北石家庄050017 [3]海南现代女子医院,海南海口570206

出　　处：《中国热带医学》2007年第9期1546-1547,1549,共3页China Tropical Medicine

摘　　要：目的通过观察稳定期不同级别慢性阻塞性肺病患者血清TNF-α、IL-8、GM-CSF水平与FVC、FEV1和FEV1/FVC关系,探讨血清TNF-α、IL-8、GM-CSF水平的变化对FVC、FEV1、FEV1/FVC的影响及其机制。方法在呼吸科门诊筛查的COPD患者中选取56例分为1组、2组和3组,分别检测FVC、FEV1、FEV1/FVC;用ELISA方法测定患者血清中TNF-α、IL-8、GM-CSF水平;另从患病1,2,3组中抽出10名患者为治疗1T、2T、3T组;对选定的治疗组患者口服百令胶囊30d后,检测相同指标。结果TNF-α、IL-8、GM-CSF水平在不同级别中存在差异(P<0.05),与FEV1,FVC存在着明显的负相关(P<0.05)。结论COPD细胞因子的持续升高是引起肺组织慢性损伤、功能降低的重要原因。Objective To to explore the change of serum TNF - α, IL - 8, GM - CSF level in different grade and their effect on FVEI, FVC, FEVI/FVC of COPD patients in stable stage by observing the levels of tumor necrosis factor （TNF - α）, interleukin - 8（IL-8）, granulocyte macrophage colony stimulating factor （GM- CSF） in the serum of chronic obstructive pulmonary disease （COPD） patients in different stable grade, and their lung function, including forced vital eapacity（FVC）, forced expiratory volume one second（FEV1 ）, FEVI/FVC, as well as the relationship between these factors and lung function after treated Methods A total of 56 COPD patients from the respiratory clinic, were divided into Group 1, Group 2 and Group 3 based on GOLD grading standard. The levels of FVC, FEV1, FEV1/FVC were determined. Ten patients were randomly chosen from the three groups served as Treatment Groupl, 2 and 3, the levels of FVEI, FVC, FEVI/FVC were determined, while the levels of TNF - α, IL - 8, and GM - CSF in serum were determined 30 days after orally adminstration of Bailing capsule. Results The levels of FEVI, FVC, FEVI/ FVC are significantly different in various grades （ P 〈 0. 05 ） . The levels of TNF - α, IL - 8, and GM - CSF were nngatively correlated with that of FEV1 and FVC. Conclusion The continuous increase of COPD cytokine is an important cause resulting in the chronic lesions in pulmonary tissues and the lowerig of pulmonary function.

关 键 词：慢性阻塞性肺病 呼吸功能试验 用力肺活量 第一秒钟用力呼气容积 肿瘤坏死因子-α 白介素-8 粒-巨细胞集落刺激因子 

分 类 号：R563.5[医药卫生—呼吸系统]