2型糖尿病大鼠糖代谢异常及仙人掌粉的干预效应  被引量:1

Interventional Effect of Opuntia on the Blood Glucose Level in Type II Diabetic Rats

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作  者:崔美芝[1] 刘浩[2] 董娟[2] 

机构地区:[1]哈尔滨医科大学第一临床医学院实验动物中心,哈尔滨150001 [2]哈尔滨医科大学第一临床医学院检验科,哈尔滨150001

出  处:《中国比较医学杂志》2007年第8期493-495,共3页Chinese Journal of Comparative Medicine

基  金:黑龙江攻关课题资助项目;编号SYOZ-04。

摘  要:目的研究仙人掌粉对2型糖尿病(T2DM)大鼠血糖的影响及其机制。方法用高糖高脂饲料喂养加小剂量链脲佐菌素(STZ)注射造成2型糖尿病模型,然后将大鼠分成6组:正常对照组(N)喂普通饲料,糖尿病对照组(A)、苯乙双胍组(B)喂高糖高脂饲料,仙人掌大(C)、中(D)、小(E)剂量组喂仙人掌粉(9g/d只、6g/d只、3g/d只)和高糖高脂饲料,4周后测空腹血糖。结果C、D、E各组血糖值都有所降低(9.21±0.85、11.35±0.91、14.40±1.30),与实验前比较C、D组差异均有显著性(P<0.01),与A组比较差异显著(P<0.01),与B组比较差异不显著(P>0.05)。结论仙人掌粉能够降低2型糖尿病大鼠血糖值,作为药食两用的野生植物具有极大的开发和利用价值。Objective To study the effect of Opuntia on the blood glucose level in rat model of type Ⅱ diabetes mellitus. Method Rat model of type Ⅱ diabetes mellitus (DM) was eastablishod with streptozotocin (STZ) 60 rats with DM were divided into six groups (10 rats each) : normal control (N), DM control (A), PEDG (B), and low dose (E, fed with 3 g/d), moderate dose (D, fed with 6 g/d) and high dose (C, fed with 9 g/d) of Opuntia. Results The blood glucose levels in C (9.21 0. 85), D (11.35 0.91 ) and E( 14.40 1 .30) groups were significantly decreased in comparison with that before Opuntia administration in groups C and D ( P 〈 0.01 ), and also significant difference compared with group A ( P 〈 0.01 ), but not with group B ( P 〉 0.05) Conclusion Opuntia may decrease the blood glucose level in rat model of type Ⅱ diabetes mellitus, and is worth further studing on its clinical application.

关 键 词:2型糖尿病 链脲佐菌素 仙人掌 大鼠 

分 类 号:R965.1[医药卫生—药理学] R587.1[医药卫生—药学]

 

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