多层螺旋CT在高过载作用致猴脑部损伤研究中的应用  

Application of MSCT in Research of +Gx on Brain Injury in Rhesus

作　　者：费军[1] 吴斌[2] 张朝利[1] 姜世忠[2] 刘瑛琪[1] 王宗烨[1] 郑冬[1] 陈宁[1] 赵亮[1] 

机构地区：[1]中国人民解放军第306医院,北京100101 [2]航天医学工程研究所,北京100094

出　　处：《放射学实践》2007年第8期790-792,共3页Radiologic Practice

基　　金：总装备部航天医学科研基金资助课题(HTYK02006)

摘　　要：目的:观察飞船应急返回高过载致猴脑部损伤的影像学改变。方法:6只健康雄性成年恒河猴被随机分为+15Gx组和+21Gx组,分别在动物离心机上承受相应峰值的抛物线形过载曲线作用;6只恒河猴分别在实验前、实验后2h、24h、7d行多层螺旋CT(MSCT)检查。结果:+15Gx组和+21Gx组在过载作用后2h、24h大脑呈缺血性改变,1周后血流灌注基本恢复正常。结论:飞船应急返回高过载可引起脑部损伤,MSCT脑灌注成像可提供有效的诊断信息,脑部损伤程度与+Gx值有很好的正相关关系。Objective：To observe image changes of brain injury of rhesus by high G during spaceship emergency re turn. Methods：Six healthy male adult rhesuses were randomly divided into ＋ 15Gx and ＋ 21Gx group and respectively un derwent corresponding parabolic G curve in animal centrifuge. The animals were all examined by MSCT scan before ＋ Gx exposure and 2h, 24h, 7d after ＋Gx exposure. Results： 2h and 24h after ＋ 15Gx and ＋ 21Gx exposure, brain ischemia was shown on CT cerebral perfusion imaging. 7d later, brain ischemia images were almost recovered to normal. Conclusion： High G from simulating spaceship emergency return can cause ischemic injuries on brain of the rhesus. CT brain perfusion imaging can provide valuable diagnostic information. There is a significant correlation of the degree of brain damage with the level of ＋Gx load.

关 键 词：体层摄影术 X线计算机 灌注 脑损伤 

分 类 号：R85[医药卫生—航空、航天与航海医学]