临床常用抗生素对G^-致病菌的效价分析  

Analysis on the Potency of the Commonly Used Antibiotics for G-pathogenic Bacteria

作　　者：吴燕[1] 

机构地区：[1]湖南省南华大学第一附属医院药剂科,湖南衡阳421001

出　　处：《现代生物医学进展》2007年第9期1345-1348,共4页Progress in Modern Biomedicine

摘　　要：目的:调查我院常用抗生素的种类及其对,临床常见的G^-致病菌的效价情况,为合理选用抗生素提供临床资料。方法:从2246个样本中分离到646株G^-致病茵,用全自动微生物分析仪-VITEK 32进行菌种鉴定及20种抗生素的药敏实验。结果:646株G^-致病菌经鉴定属于14大类,其中铜绿假单胞菌160株,占24.77%;大肠埃希氏菌135株,占20.90%;鲍曼不动杆菌90株,占13.93%;克雷伯菌属116株,占17.96%;其它9种G^-致病菌所占的比例均小于7%。头孢类抗生素是目前最为常用的。在检测的20种抗生素对检测的14种G^-致病菌的效价最高的前三位分别是:亚胺培南(IMP)82.66%、美洛西林(MEZ)81.15%、环丙沙星(CIP)61.06%;效价最差的三位分别是:头孢呋辛(CFO)23.76%、头孢噻吩(CEP)26.74%、替卡西林(TIC)31.58%。结论:经典的抗生素对G^-致病菌的效价不容乐观,且非科学的联合用药可能会降低药效。Objective： In order to provide the data resource for clinicians adopting antibiotics properly, we have researched the variety of the commonly used antibiotics and their potency for the common pathogenic bacteria G^- in our hospital, Methods： 646 stains of the pathogenic bacteria G^- have been segregated from 2246 samples, then the automatic microbion analysator VITEK 32 was used to identify strains and test the drug susceptibility of 20 antibiotics. Results： 646 strains of pathogenic bacteria G^- belong to 14 categories, among which there are 160 strains of pseudomonas aeruginosa with a proportion of 24.77%; 135 swains of Escherichia coli, of 20.90%; 90 Baumanii, of 13.93%; 116 Klebsiella oxytoca, of 17.96%; the other nine pathogenic bacteria G^- with a proportion less than 8%. Cephalosporin antibiotics were the most frequently used antibiotic. Among the 20 kinds of antibiotics tested, Imipenem, Mezlocillin and Ciprofloxacin have the best potency of 82.66%, 81.15%, and 61.06%, respectively, for 14 pathogenic bacteria G^-. The antibiotics with a generally bad potency are Cefuroxime, Cefalotin and Cafalotin, with a respectively sensitivity rate of 23.76%, 26.74% and 31.58%. Conclusion： The potency of classic antibiotics for the pathogenic bacteria G^- is not optimistic, and the inappropriate combined medication would cut down its pharmacodynamic action.

关 键 词：抗生素 G^-致病菌 耐药性 

分 类 号：R117[医药卫生—公共卫生与预防医学]