水相法合成毒死蜱  

Aqueous Phase Synthesis of Chlorpyrifos

作　　者：胡跃华[1] 胡辉[1] 宋雪斌[1] 

机构地区：[1]浙江新安化工集团股份有限公司,杭州311600

出　　处：《农药》2007年第9期594-595,共2页Agrochemicals

摘　　要：以2,3,5,6-四氯吡啶、液碱为原料在高压釜中反应得到3,5,6-三氯吡啶醇钠,收率99.6%。3,5,6-三氯吡啶醇钠与乙基氯化物经水相法合成毒死蜱,选三甲基苄基氯化铵为缩合催化剂,3,5,6-吡啶醇钠与乙基氯化物摩尔比为1∶1,pH值控制在11～13,反应温度为60℃,反应时间3h,毒死蜱的收率、含量分别在94%和97%以上。3,5,6-Trichloro-2-pyridinol sodium with yield of 99.6% was prepared from 2,3,5,6-tetrachloropyridine and caustic sodium as raw material via High Pressure Autoclave. Chlorpyrifos was synthesized by reacting of 3,5,6-trichloro-2-pyridinol sodium（1 mol） with O,O-diethyl phosphorochloridothioate（1 mol） via aqueous phase（pH=11-13） reaction and benzyltrimethyl ammonium chloride as catalyst at 60 °C for 3 hrs,and the yield and purity of chlorpyrifos were over 94% and 97%,respectively.

关 键 词：2 3 5 6-四氯吡啶 3  5  6-三氯吡啶醇钠 毒死蜱 水相法 

分 类 号：TQ453[化学工程—农药化工]