头孢唑林钠联合甲硝唑预防剖宫产围手术期感染的临床研究  

Clinical study on coadministration of cefazolin sodium and metronidazole for infection prophylaxis in perioperative period of cesarean section

作　　者：邓大明[1] 黄桢[1] 苑文军[1] 丁丽珠[1] 陈向宇[1] 

机构地区：[1]上海市长宁区中心医院药剂科,上海200336

出　　处：《药学服务与研究》2007年第4期278-280,共3页Pharmaceutical Care and Research

摘　　要：目的:比较头孢唑林钠与青霉素钠预防剖宫产围手术期感染的疗效。方法:100例择期行剖宫产手术的病人被随机分为试验组(n=48)和对照组(n=52),进行前瞻性随机对照试验。试验组术中和术后第1天分别静脉滴注头孢唑林钠2 g和0.5%甲硝唑200 mL。对照组术中静脉滴注氨苄西林钠3 g和0.5%甲硝唑200 mL;术后静脉滴注0.5%甲硝唑200 mL,qd,1 d,氨苄西林钠3 g和青霉素钠400万单位,bid,3 d。比较两组病人的感染情况、用药天数和药费。结果:两组病人术后感染情况无统计学差异,均未出现药物不良反应。试验组抗菌药物用药天数、抗菌药费用和住院总药费均显著低于对照组(P<0.01)。结论:头孢唑林钠联合甲硝唑预防剖宫产围手术期感染安全、有效和经济。Objective： To compare the effectiveness of cefazolin sodium and benzylpenicillin in prophylaxis of infection in perioperative period of cesarean section. Methods： One hundred patients undergoing selected operation of cesarean section were randomly divided into two groups in a prospective controlled study. Patients in test group （n=48） were given cefazolin sodium 2 g and 0.50% metronidazole 200 mL,iv gtt,during and after the operation. Patients in control group （n=52） were given ampicillin sodium 3 g and 0.5 % metronidazole 200 mL, iv gtt, during the operation, and 0. 5 % metronidazole 200 mL （qd, 1 d） ,ampicillin sodium 3 g （bid,3 d） and benzylpenicillin sodium 4×10^6 U （bid,3 d） after the operation. Infection,duration of medication and cost of drugs in two groups were compared. Results：There was no significant difference in infection, while duration of medication,cost of antibacterial agents and total drug cost during hospitalization of test group were significantly lower than those of control group （P〈0. 01）. No adverse drug reactions were observed in all patients. Conclusion： Cefazolin sodium combined with metronidazole was effective, safe and economical for antibiotic prophylaxis in perioperative period of cesarean section.

关 键 词：头孢唑林 剖宫产术 抗生素预防 临床对照试验 

分 类 号：R978.1[医药卫生—药品] R969.4[医药卫生—药学]