益气活血解毒汤对实验性动脉粥样硬化家兔血脂、前列环素及血栓素A_2的影响  

Effects of Yiqihuoxuejiedu Decoction on Serum Lipid,PGI_2 and TXB_2 in Rabbits with Experimental Atherosclerosis

作　　者：李忠志[1] 杨明[1] 孙薇[1] 胡业彬[2] 

机构地区：[1]安徽中医学院 [2]安徽省中医院

出　　处：《中西医结合心脑血管病杂志》2007年第9期823-824,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：安徽省教育厅自然科学基金项目(No.2006KJ340B)

摘　　要：目的通过高脂饲料喂饲诱发动脉粥样硬化家兔模型,探讨中药复方益气活血解毒汤对家兔动脉粥样硬化的干预作用及其作用机制。方法24只日本雄性大耳白兔随机分为4组,分别为空白对照组、模型对照组、益气活血解毒汤组及辛伐他汀组。10周后测定各组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血栓素B2(TXB2)、6-酮-前列腺素(6-keto-PGF1α)的含量。结果模型对照组TC,TG,LDL-C,TXB2较空白对照组有不同程度升高(P<0.05或P<0.01),6-keto-PGF1α及HDL-C显著下降(P<0.05)。益气活血解毒汤组及辛伐他汀组TC,TG,LDL-C及TXB2均低于模型对照组,6-keto-PGF1α及HDL-C升高明显(P<0.01),益气活血解毒汤组HDL-C与辛伐他汀组比较有所升高(P<0.05)。结论益气活血解毒汤对家兔动脉粥样硬化有明显的预防和治疗作用,调节血脂、维持PGI2/TXA2的平衡可能是其作用机制之一。Objective To study the effect of Yiqihuoxuejiedu Decoction on rabbits with atherosclerosis. Methods Twenty- four Japanese white rabbits were divided randomly into four groups： Control group, model group, Yiqihuoxuejiedu decoction group and simvas rain group. After ten weeks, the concentration of total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol （HDL- C）, low density lipoprotein cholesterol （ LDL - C）, 6 - keto PGF1α and TXB2 were measured. Results Compared with the control group, the level of TC, TG, HDL - C, LDL - C and TXB2 increased （ P 〈 0.05 or P 〈 0.01 ）. 6 - keto - IPGF1α HDL - C deceased significantly（ P 〈 0.01 ）in models group. Compared with the model group, the concentration of TC, TG, LDL - C and TXB2 deceased and 6 - keto - PGF1α and HDL - C increased obviously （ P 〈 0.01 ） in Yiqihuoxuejiedu decoction group and Simvastain group. Compared with the simvastain group, the level of HDL- C increased in Yiqihuoxuejiedu decoction （P 〈 0.05 ）. Conclusion Yiqihuoxuejiedu decoction was effective for treatment and prevention of atherosclerosis. It might be related to regulate the serum lipid and PG12/TXA2.

关 键 词：动脉粥样硬化 益气活血解毒汤 血脂 6-酮-前列腺素 血栓素B2 

分 类 号：R285.5[医药卫生—中药学]