豚鼠变应性鼻炎模型鼻黏膜的病理改变  

Pathological changes of the nasal mucosa of guinea pigs with allergic rhinitis

作　　者：吉晓滨[1] 杜洪[2] 臧林泉[3] 李雯[2] 谢军[3] 王磊[1] 

机构地区：[1]广州市第一人民医院耳鼻咽喉科,广东广州510180 [2]广州市第一人民医院病理科,广东广州510180 [3]中山大学基础医学院药理学教研室,广东广州510006

出　　处：《山东大学耳鼻喉眼学报》2007年第4期312-315,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：广州市卫生局中医药中西医结合项目基金资助(2004A011)

摘　　要：目的:观察变应性鼻炎鼻黏膜的病理变化。方法:用橄榄油将甲苯-2,4-二异氰酸酯配成浓度为10%的溶液作为致敏剂,滴鼻,建立豚鼠变应性鼻炎动物模型8例。8例正常豚鼠作对照。致敏结束、模型成功后,取两组鼻黏膜组织,光镜下观察病理变化。结果:模型组鼻黏膜上皮脱落,杯状细胞增生,鳞状上皮组织转化,上皮坏死,固有层和黏膜下层腺体增生,血管扩张,组织水肿,并见特征性的嗜酸性粒细胞、肥大细胞浸润,这种病理改变与变应性鼻炎的临床表现大致吻合。对照组鼻黏膜上皮层为假复层纤毛柱状上皮,连续、完整、清晰,可见正常的黏膜上皮层、固有层和黏膜下层。结论:变应性鼻炎鼻黏膜出现特征性的炎症病理改变。Objective： To investigate the pathological changes of the nasal mucosa in guinea pigs with allergic rhinitis. Methods： Toluene 2, 4-diisocyanate was mixed with florence oil in a concentration of 10% and this solution was dripped into the nostrils to induce a sensitization process. Eight guinea pigs were established with allergic rhinitis by this solution and another 8 were used as controls. Nasal mucosa tissues were observed under a light microscope. Results： False multiple coat cilium columnar epithelial cells of the nasal mucosa in the control group were found successive, intact and distinct. Normal mucosal epithelium, lamina propria and submucosa were also found in the control group. However, in the experimental group mucosal epithelium was damaged and shed, goblet cells were proliferated, squamose metaplasm and epithelial necrosis occurred, serous glands in the lamina propria were vigorously proliferated, blood vessels were expanded, tissue edema was formed, and plenty of inflammatory cells such as eosinophil and mast cells were present in great number and infiltrated, which were all roughly identical to the clinical manifestations of allergic rhinitis. Conclusion： The nasal mucosa in allergic rhinitis has characteristics of inflammatory pathological changes.

关 键 词：鼻炎 变应性 疾病模型 动物 鼻黏膜 病理学 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]