赴美移民多种疫苗同时接种安全性的前瞻性研究  

A Prospective Study on the Safety of Simultaneous Vaccination to Chinese-American

作　　者：李华[1] 何洪涛[1] 王舜钦[1] 高锦平[1] 陈建东[1] 雷兆良[1] 冯心文[1] 

机构地区：[1]广东国际旅行卫生保健中心,广州510130

出　　处：《中国计划免疫》2007年第4期386-390,共5页Chinese Journal of Vaccines and Immunization

基　　金：广东出入境检验检疫局科研项目(2004GDK07)

摘　　要：目的探讨在中国人群中开展多种疫苗不同部位同时接种的安全性,为其进一步推广提供科学依据。方法选择2004年6月～2006年8月到广东国际旅行卫生保健中心接受预防接种的赴美移民申请者为调查对象,采用自填式调查表和电话报告相结合的方法收集受种者接种后不良反应情况,并与国外研究结果进行比较。结果772名受种者,接种后7d内不良反应报告率为49.6%,其中局部反应报告率为39.8%,全身反应为20.1%,与国外同类研究结果相仿。Logistic回归分析发现,女性不良反应报告率显著高于男性,接种23价肺炎球菌多糖疫苗者局部反应报告率较高,而同时接种疫苗针次未纳入回归模型。结论多种疫苗不同部位同时接种所出现的不良反应较轻微,其发生率不会因同时接种多种疫苗而增加;在中国人群中开展多种疫苗同时接种是安全可行的。Objective To study the safety of simultaneous vaccination for Chinese People in order to get scientific data to improve the vaccination. Methods A prospective observational study was conducted in 772 Chinese-American immigrants who were vaccinated in our Center during June 2004 to August, 2006. Data about adverse reactions were collected through the ways of self-administered questionnaire and tel-reporting. Results General reactions were reported by 49.6% vaccinees, with 39.8% reporting local reactions and 20. 1% reporting systemic reactions, which were similar to the results of the foreign studies. By logistic regression analysis, it was shown that systemic and local reactions were experienced more frequently by women and local reactions significantly associated with PPV vaccination,while number of vaccinations given simultaneously did not associate with the occurrence of adverse reactions significantly. Conclusion The adverse reactions after simultaneous vaccination were generally minor and acceptable and simultaneous vaccination was feasible and safe for Chinese People.

关 键 词：预防接种 同时接种 疫苗 不良反应 

分 类 号：R186[医药卫生—流行病学]