加替沙星和左氧氟沙星注射液对血糖影响的回顾性队列研究  

Effects of gatifloxacin and levofloxacin on blood glucose:a retrospective cohort study

作　　者：周颖[1] 路敏[1] 田硕涵[1] 梁雁[1] 张慧琳[1] 崔一民[1] 张俊[2] 张黎明[2] 詹思延[3] 

机构地区：[1]北京大学第一医院药剂科,北京100034 [2]北京市药品不良反应监测中心,北京100024 [3]北京大学公共卫生学院,北京100083

出　　处：《药物不良反应杂志》2007年第4期235-238,共4页Adverse Drug Reactions Journal

摘　　要：目的:调查加替沙星注射液对血糖的影响,并与左氧氟沙星注射液比较。方法:采用回顾性队列研究,收集我院2005年9月至2006年8月,使用加替沙星注射液或左氧氟沙星注射液治疗感染性疾病的住院患者300例,分为2组:加替沙星组150例(糖尿病患者35例,非糖尿病患者115例),给予加替沙星400mg/d静脉滴注;左氧氟沙星组150例(糖尿病患者38例,非糖尿病患者112例),给予左氧氟沙星200～500mg/d静脉滴注。分析2组患者血糖的变化。结果:加替沙星组发生血糖异常6例(发生率为4.0%),左氧氟沙星组发生血糖异常1例(发生率0.7%),2组相比差异有统计学意义(P=0.044)。加替沙星组糖尿病患者中血糖升高2例(5.71%),血糖降低1例(2.86%),兼有血糖降低和升高者2例(5.71%);非糖尿病患者中血糖升高1例(0.87%)。左氧氟沙星组38例糖尿病患者中兼有血糖降低和升高者1例(2.6%)。结论:加替沙星引起血糖异常的发生率高于左氧氟沙星。对应用加替沙星的患者,尤其是糖尿病患者应加强血糖监测。Objective： To investigate the effects of gatifloxacin on blood glucose metabolism, and compared those with levofloxacin. Methods： In a retrospective cohort study, 300 hospitalized patients with infectious diseases while receiving gatifloxacin or levofloxacin in our hospital from September 2005 to August 2006 were assigned to two groups： gatifloxacin group （150 cases： diabetics 35 and nondiabetics 115） and levofloxacin group （150 cases： diabetics 38 and nondiabetics 112）. The patients in the gatifloxacin group were administered with IV gatifloxacin 400 mg daily. The patients in the levofloxacin group were administered with IV levofloxacin 200-500 mg daily. The changes of blood glucose were analyzed in the two groups. Results： Dysglycemia in the gatifloxacin group was 6 cases （4.0%） and in the levofloxacin group was 1 case （0.7%）. The differences between the two groups were statistically significant （P-~）.044）. In the galifloxacin group, of the diabetic patients, 2 （5.71%） were hyperglycemia, 1 （2.86%） was hypoglycemia, and 2 （5.71%） were both hypoglycemia and hyperglycemia; of the nondiabeticy patients, 1（0.87%） was hyperglycemia. In the levofloxacin group, of 38 diabetic patients, 1 （2.6%） was both hypoglycemia and hyperglycemia. Conclusion.. The incidence of dysglycemia related to gatifloxacin is higher than that of levofloxacin. Blood glucose levels should be monitored carefully when gatifloxacin is used in patients, especially in diabetic patients.

关 键 词：加替沙星 左氧氟沙星 血糖异常 

分 类 号：R96[医药卫生—药理学]