补肾壮骨冲剂治疗绝经后妇女骨质疏松疼痛的效果分析  

Effect of Bushen Zhuanggu Granule on Relieving Pain in Menopausal Osteoporosis Patients

作　　者：邓伟民[1] 邵玉[2] 张金玉[1] 马建青[1] 崔伟历[1] 韦蒿[1] 贺扬淑[1] 

机构地区：[1]广州军区广州总医院,广州510010 [2]广州中医药大学,2005级研究生广州510405

出　　处：《广州中医药大学学报》2007年第5期355-358,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省科技计划项目(编号:2005B40301005)

摘　　要：【目的】观察补肾健脾基础上加强化瘀药物制成的补肾壮骨冲剂对绝经后妇女骨质疏松疼痛程度的影响。【方法】按数码随机表将178例患者随机分为2组,补肾壮骨冲剂组88例,失访8例;密盖息组90例,失访4例。补肾壮骨冲剂组给予口服补肾壮骨冲剂(由生地、淮山药、山萸肉、泽泻、茯苓、肉桂、淫羊藿、鹿角胶、龟胶、巴戟天、骨碎补、三棱、水蛭等组成);密盖息组给予密盖息肌肉注射治疗。分别于治疗前和治疗1、2、3、4、6周观察两组的疼痛强度、疼痛缓解度、镇痛有效率。【结果】①疼痛强度比较:与治疗前比较,所有患者治疗后疼痛显著性好转(P<0.01);组间比较:治疗第1、2、3周密盖息组疼痛强度低于补肾壮骨冲剂组(P<0.05),而治疗第4、6周两组无显著性差异(P>0.05)。②疼痛缓解情况比较:治疗第1周,补肾壮骨冲剂组未缓解率显著性高于密盖息组(P<0.01),其余则无显著性差异(P>0.05);③有效率比较:除治疗第2周补肾壮骨冲剂组显效率低于密盖息组(P<0.01)外,其他均无显著性差异(P>0.05)。【结论】补肾壮骨冲剂可明显缓解绝经后妇女骨质疏松患者的疼痛,其疗效与密盖息相仿。[ Objective] To observe the effect of Bushen Zhuanggu Granule （BZG）, a prescription with the actions of tonifying kidney, strengthening spleen and removing blood-stasis, on relieving pain in menopausal osteoporosis （MO） women patients. [ Methods ] One hundred and seventy-eight MO patients were randomized into two groups. Group A （N = 88, 8 loss of follow-up） received BZG, which is mainly composed of Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Comi, Rhizoma Alismatis, Poria, Cortex Cinnamomi, Hema Epimedii, Colla Comus Cervi, Carapax et Plastrum Testudinis, Radix Morindae Officinalis, Rhizoma Drynariae, Rhizoma Sparganii, Rhizoma Curcumae, etc. Group B （N = 90, 4 loss of follow-up） received intramuscular injection of miacalcic （calcitonin）. The degree of pain, pain relief and effective rate for pain relief were observed before treatment and after treatment for 1, 2, 3, 4 and 6 weeks. [ Results] Pain was relieved in the two groups after treatment （P 〈0. 01 compared with that before treatment）. The pain degree was lower in group B than that in group A after treatment for 1, 2 and 3 weeks （P 〈 0. 05 ）, but was similar in the two groups after treatment for 4 and 6 weeks （P 〉 0.05 ）. The pain un-relieved rate was higher in group A than that in group B after treatment for one week （ P 〈 0. 01 ）, and then was similar in the two groups after treatment for 2, 3, 4 and 6 weeks （ P 〉 0. 05）. The markedly effective rate in group A was lower than that in group B after treatment for 2 weeks （P 〈 0.01 ）. However, the effective rate and total effective rate after treatment for 2 weeks, as well as the markedly effective rate, the effective rate and total effective rate after treatment for 4 and 6 weeks were similar in the two groups （ P 〉 0. 05 ）. [ Conclusion ] BZG can obviously relieve the pain in MO patients, and its effect is similar to miacalcic.

关 键 词：骨质疏松/中药疗法 疼痛/中药疗法 补肾 健脾 补肾壮骨冲剂/治疗应用 

分 类 号：R271.9[医药卫生—中西医结合]