有序壳聚糖膜的制备及降解性能研究  

Preparation and biodegradability of a new orderly membrane of chitosan

作　　者：李学习[1] 唐丹妹[1] 赵逸云[1] 杨■金 陈德义[1] 

机构地区：[1]云南大学化学系教育部自然资源药物化学重点实验室,云南昆明650091

出　　处：《云南大学学报（自然科学版）》2007年第5期501-503,共3页Journal of Yunnan University(Natural Sciences Edition)

基　　金：云南省自然科学基金资助项目(2004E0009M)

摘　　要：以三聚磷酸钠(TPP)作交联剂,用2次交联法,制备了一种新的有序壳聚糖交联膜(CS/TPP),并用溶菌酶对其进行了体外降解性研究,同时用隧道扫描电镜(SPM)对膜进行了表征.结果表明:有序CS/TPP膜有着致密有序的结构和良好的生物可降解性.A Firstly, nonasized new orderly chitosan （CS） membrane was prepared and its biodegradability was studied. chitosan microspheres were prepared from a dilute solution of chitosan in HAc, using sodium tripolyphosphate （TPP） as c tosan microspheres and TPP. CS/TPP membrane could be ing 16 weeks. The study h could be a potential carrier ross-linking agent. Then, an orderly membrane was cast from a solution of chiThe result of vitro degradation experiment showed that the orderly cross-linked biodegraded by lysozyme, the weight loss of the membrane was about 32% durindicated that the membranehas order structure and good biodegradability and for drug controlled releasing.

关 键 词：壳聚糖 有序膜 药物缓释 生物降解 

分 类 号：O636.1[理学—高分子化学]